RAPID EVOLUTION OF THE HUMAN GENE FOR CYTOCHROME-C-OXIDASE SUBUNIT-IV

被引：26

作者：

LOMAX, MI

HEWETTEMMETT, D

YANG, TL

GROSSMAN, LI

机构：

[1] UNIV TEXAS,HLTH SCI CTR,CTR DEMOG & POPULAT GENET,HOUSTON,TX 77225

[2] WAYNE STATE UNIV,SCH MED,DEPT MOLEC BIOL & GENET,DETROIT,MI 48201

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 12期

关键词：

RESPIRATORY CHAIN; PRIMATE; MITOCHONDRIAL PROTEIN; NUCLEAR GENE; COEVOLUTION;

D O I：

10.1073/pnas.89.12.5266

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have compared the DNA sequences of nine mammalian genes for cytochrome c oxidase subunit IV (COX4 genes)-four expressed genes (human, bovine, rat, and mouse) and five pseudogenes (human, chimpanzee, orangutan, squirrel monkey, and bovine)-and constructed the sequence of the ancestral mammalian COX4 gene. By analyzing these sequences to determine the pattern and rate of nucleotide substitution in each branch of the evolutionary tree, we deduced that the human gene has evolved rapidly since the origin of the primate pseudogene approximately 41 million years ago, and we discuss the suggestion that this results from coevolution of nuclear and mitochondrial genes for cytochrome c oxidase.

引用

页码：5266 / 5270

页数：5

共 33 条

[1] 2 BOVINE GENES FOR CYTOCHROME-C-OXIDASE SUBUNIT-IV - A PROCESSED PSEUDOGENE AND AN EXPRESSED GENE [J].