REPETITIVE APNEAS INDUCE PERIODIC HYPERTENSION IN NORMAL SUBJECTS THROUGH HYPOXIA

被引:75
作者
VANDENAARDWEG, JG
KAREMAKER, JM
机构
[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT INTERNAL MED,1105 AZ AMSTERDAM,NETHERLANDS
[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT PHYSIOL,1105 AZ AMSTERDAM,NETHERLANDS
关键词
BLOOD PRESSURE; CHEMOREFLEX; HEART RATE; PARASYMPATHETIC NERVOUS SYSTEM; SLEEP APNEA SYNDROME; SYMPATHETIC NERVOUS SYSTEM;
D O I
10.1152/jappl.1992.72.3.821
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Periodic increases in blood pressure (BP) can occur in the sleep apnea syndrome (SAS) during recurrent apneas. To investigate the mechanisms causing this periodic hypertension, we simulated SAS by imposing a matching breathing pattern on seven healthy awake male volunteers. Continuous finger arterial BP, electrocardiogram, arterial O2 saturation (Sa(o2)), end-tidal CO2, and tidal volume were measured. The role of hypoxia was studied by comparing apneas during depletion of O2 in the spirometer with those during 100% O2 breathing. In all subjects, BP periodically reached values > 150/95 mmHg in the hypoxic series. During the hyperoxic apnea series, however, BP remained stable. End-apneic mean BP was shown to be inversely correlated to Sa(o2) in six subjects in the Sa(o2) range from 60 to 100%. Although the hypoxic BP pattern closely mimicked that in SAS, the heart rate pattern in four of our subjects remained distinct from that in patients. Atropine could not prevent large BP swings in the hypoxic series. We conclude that Sa(o2) is a major determinant of periodic hypertension in recurrent apneas. Its effect probably results from chemoreflex modulation of peripheral resistance.
引用
收藏
页码:821 / 827
页数:7
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