A NEW CHIRAL ALKYLATION METHODOLOGY FOR THE SYNTHESIS OF 2-ALKYL-4-KETOACIDS IN HIGH OPTICAL PURITY USING 2-TRIFLYLOXY ESTERS

被引：22

作者：

HOFFMAN, RV

KIM, HO

机构：

[1] Department of Chemistry, Biochemistry New Mexico State University Las Cruces

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)60343-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active 2-triflyloxy esters are excellent alkylating agents for beta-ketoester enolates. Decarbaxylation of the alkylation products gives 2-substituted-4-ketoacid derivatives in high optical purities.

引用

页码：2051 / 2054

页数：4

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