A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (-)-ANTIRHINE BY CHEMOENZYMATIC APPROACH

被引：26

作者：

DANIELI, B ^{[1
]}

LESMA, G ^{[1
]}

MAURO, M ^{[1
]}

PALMISANO, G ^{[1
]}

PASSARELLA, D ^{[1
]}

机构：

[1] UNIV MILAN,CNR,CTR SOSTANZE ORGAN NAT,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

来源：

TETRAHEDRON | 1994年 / 50卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(01)85357-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Antirhine 2 was synthesized in an efficient and stereocontrolled fashion from the readily available (1R-2S)-cyclohexene dimethanol monoacetate 6. A key step was the regio- and stereoselective Pictet Spengler cyclization of the masked dialdehyde 12 to the indoloquinolizidinone 13.

引用

页码：8837 / 8852

页数：16

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