NEUROMUSCULAR FACILITATION INDUCED BY MUSCARINIC ANTAGONISTS IN THE RAT ISOLATED DIAPHRAGM

被引：6

作者：

ALVESDOPRADO, W ^{[1
]}

PRADO, WA ^{[1
]}

机构：

[1] FAC MED RIBEIRAO PRETO,DEPT PHARMACOL,BR-14049 RIBEIRAO PRET,SP,BRAZIL

来源：

GENERAL PHARMACOLOGY | 1993年 / 24卷 / 06期

关键词：

D O I：

10.1016/0306-3623(93)90443-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Atropine (EC50 = 87 muM), pirenzepine (447 muM), and AF-DX 116 (95.5 muM), but not 4-DAMP (at concentrations of up to 110 muM), produced neuromuscular facilitation and antagonized the oxotremorine-induced neuromuscular blockade in the rat isolated diaphragm. 2. Atropine, pirenzepine, and AF-DX 116 did not change the responses of curarized diaphragms to direct stimulation, or the twitch tension produced by retrograde injection of acetylcholine. 3. These results indicate that neuromuscular facilitation induced by muscarinic antagonists may depend on drug interaction with the M2 subtype of muscarinic autoreceptors to increase acetylcholine output in the neuromuscular junction.

引用

页码：1501 / 1504

页数：4

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