HISTIDINE AND ASPARTATE PHOSPHORYLATION - 2-COMPONENT SYSTEMS AND THE LIMITS OF HOMOLOG

被引：154

作者：

SWANSON, RV

ALEX, LA

SIMON, MI

机构：

[1] R. V. Swanson, L. A. Alex and M. I. Simon are, the Division of Biology, Pasadena

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90135-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Autophosphorylating histidine kinase and response-regulator domains constitute the building blocks of two-component signaling systems. These systems use a unique phosphotransfer chemistry to regulate many aspects of bacterial physiology. Homologous systems are now being found in eukaryotes. Despite their common mechanism of phosphotransfer, the two-component systems display an extensive diversity in the arrangement of their domains, and flexibility in their roles in different signal transduction circuits.

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收藏

页码：485 / 490

页数：6

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