SELEGILINE ENHANCES SURVIVAL AND NEURITE OUTGROWTH OF MPP(+)-TREATED DOPAMINERGIC-NEURONS

被引：38

作者：

KOUTSILIERI, E

OCALLAGHAN, JFX

CHEN, TS

RIEDERER, P

RAUSCH, WD

机构：

[1] UNIV OXFORD,DEPT PHARMACOL,OXFORD OX1 3QT,ENGLAND

[2] UNIV WURZBURG,DEPT PSYCHIAT,W-8700 WURZBURG,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 269卷 / 03期

关键词：

SELEGILINE; NEURONAL RESCUE; TROPHIC FACTOR;

D O I：

10.1016/0922-4106(94)90048-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Selegiline was added to co-cultures of mesencephalon and neostriatum of C57BL/6 mouse embryos according to three schemes: (i) before and (ii) after cells were exposed to the toxin 1-methyl-4-phenylpyridinium (MPP(+)), (iii) in control cultures. In all schemes, selegiline enhanced the morphological differentiation of dopaminergic neurons and with delayed treatment, significantly increased their survival. These results indicate that selegiline exhibits trophic-like actions and can rescue MPP(+)-injured dopaminergic neurons in cultures.

引用

页码：R3 / R4

页数：2

共 8 条

[1] L-DEPRENYL INCREASES GFAP IMMUNOREACTIVITY SELECTIVELY IN ACTIVATED ASTROCYTES IN RAT-BRAIN [J].