Functions and therapeutic roles of exosomes in cancer

被引：190

作者：

Tickner, Jacob A. ^{[1
]}

Urquhart, Aaron J. ^{[1
]}

Stephenson, Sally-Anne ^{[2
]}

Richard, Derek J. ^{[1
]}

O'Byrne, Kenneth J. ^{[1
]}

机构：

[1] Queensland Univ Technol, Translat Res Inst, Canc & Ageing Res Program, Brisbane, Qld, Australia

[2] Queensland Univ Technol, Translat Res Inst, Eph Receptor Biol Grp, Brisbane, Qld, Australia

来源：

FRONTIERS IN ONCOLOGY | 2014年 / 4卷

关键词：

exosome; cancer; metastatic niche; chemotherapeutic resistance; biomarker;

D O I：

10.3389/fonc.2014.00127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, have been found to regulate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic sites for the attachment and growth of tumor tissue. Through an interaction with a range of host tissue, exosomes are able to generate a pro-tumor environment that is essential for carcinogenesis. Herein, we discuss the contents of exosomes and their contribution to tumorigenesis, as well as their role in chemotherapeutic resistance and the development of novel cancer treatments and the identification of cancer biomarkers.

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页数：8

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共 90 条

[1]

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Kerbel, Robert S. ;

Allison, Anthony C. ;

Rak, Janusz .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) :3794-3799

[2]

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[3]

Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles [J].

Andreola, G ;

Rivoltini, L ;

Castelli, C ;

Huber, V ;

Perego, P ;

Deho, P ;

Squarcina, P ;

Accornero, P ;

Lozupone, F ;

Lugini, L ;

Stringaro, A ;

Molinari, A ;

Arancia, G ;

Gentile, M ;

Parmiani, G ;

Fais, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (10) :1303-1316

[4]

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3 [J].

Aung, Thiha ;

Chapuy, Bjoern ;

Vogel, Daniel ;

Wenzel, Dirk ;

Oppermann, Martin ;

Lahmann, Marlen ;

Weinhage, Toni ;

Menck, Kerstin ;

Hupfeld, Timo ;

Koch, Raphael ;

Truemper, Lorenz ;

Wulf, Gerald G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (37) :15336-15341

[5]

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review [J].

Azmi, Asfar S. ;

Bao, Bin ;

Sarkar, Fazlul H. .

CANCER AND METASTASIS REVIEWS, 2013, 32 (3-4) :623-642

[6]

Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC [J].

Battke, Christina ;

Ruiss, Romana ;

Welsch, Ulrich ;

Wimberger, Pauline ;

Lang, Stephan ;

Jochum, Simon ;

Zeidler, Reinhard .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (05) :639-648

[7]

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells [J].

Bebawy, M. ;

Combes, V. ;

Lee, E. ;

Jaiswal, R. ;

Gong, J. ;

Bonhoure, A. ;

Grau, G. E. R. .

LEUKEMIA, 2009, 23 (09) :1643-1649

[8]

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS [J].

Beckler, Michelle Demory ;

Higginbotham, James N. ;

Franklin, Jeffrey L. ;

Ham, Amy-Joan ;

Halvey, Patrick J. ;

Imasuen, Imade E. ;

Whitwell, Corbin ;

Li, Ming ;

Liebler, Daniel C. ;

Coffey, Robert J. .

MOLECULAR & CELLULAR PROTEOMICS, 2013, 12 (02) :343-355

[9]

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression [J].

Bobrie, Angelique ;

Krumeich, Sophie ;

Reyal, Fabien ;

Recchi, Chiara ;

Moita, Luis F. ;

Seabra, Miguel C. ;

Ostrowski, Matias ;

Thery, Clotilde .

CANCER RESEARCH, 2012, 72 (19) :4920-4930

[10]

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway [J].

Cai, Zhijian ;

Yang, Fei ;

Yu, Lei ;

Yu, Zhou ;

Jiang, Lingling ;

Wang, Qingqing ;

Yang, Yunshan ;

Wang, Lie ;

Cao, Xuetao ;

Wang, Jianli .

JOURNAL OF IMMUNOLOGY, 2012, 188 (12) :5954-5961

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