EMBRYOTOXIC EVALUATION OF BIS (TRI-NORMAL-BUTYLTIN)OXIDE (TBTO) IN MICE

被引：12

作者：

BARONCELLI, S ^{[1
]}

KARRER, D ^{[1
]}

TURILLAZZI, PG ^{[1
]}

机构：

[1] IST SUPER SANITA,TOSSICOL COMPARATA & ECOTOSSICOL LAB,VIA REGINA ELENA 299,I-00161 ROME,ITALY

来源：

TOXICOLOGY LETTERS | 1990年 / 50卷 / 2-3期

关键词：

Embryotoxicity; Maternal toxicity; Mouse; TBTO;

D O I：

10.1016/0378-4274(90)90018-H

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Pregnant mice were treated on days 6-15 of gestation with 5, 20 and 40 mg/kg/d bis (tri-n-butyltin)oxide (TBTO), and sacrificed on gestational day 17. At the highest dose TBTO caused a significant reduction of maternal body weight gain and also proved to be highly embryotoxic. Necropsy showed a dose-related decrease in spleen weight while a dose-dependent increase in placental weight was observed. © 1990.

引用

页码：257 / 262

页数：6

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