IMMUNIZATION OF RABBITS WITH MOSQUITO BITES - IMMUNOBLOT ANALYSIS OF IGG ANTIMOSQUITO ANTIBODIES IN RABBIT AND MAN

被引:20
作者
BRUMMERKORVENKONTIO, H
LAPPALAINEN, P
REUNALA, T
PALOSUO, T
机构
[1] NATL PUBLIC HLTH INST,MANNERHEIMINTIE 166,SF-00300 HELSINKI,FINLAND
[2] UNIV TAMPERE,DEPT CLIN SCI,SF-33101 TAMPERE 10,FINLAND
来源
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 93卷 / 01期
关键词
D O I
10.1159/000235273
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Rabbits immunized with 50-60 Aedes communis mosquito bites developed IgG antibodies recognizing a 21.5-kD mosquito antigen detected by the immunoblot technique. This protein seems to be a major immunogen in the saliva of A. communis mosquitoes. Studies on 60 human sera revealed that IgG antibodies recognizing the 21.5-kD antigen occured in about 50% of young children and adults but were not found in the sera of 20 unexposed infants. The present immunoblot method allows further characterization of antigens and antibodies specific to mosquito saliva and contributes to understanding their role in mosquito bite reactions.
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页码:14 / 18
页数:5
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