TOLERANCE TO ANTI-PENTYLENETETRAZOL EFFECTS FOLLOWING CHRONIC DIAZEPAM

被引：29

作者：

GONSALVES, SF

GALLAGER, DW

机构：

[1] YALE UNIV, SCH MED, CONNECTICUT MENTAL HLTH CTR, DEPT PSYCHIAT, NEW HAVEN, CT 06508 USA

[2] YALE UNIV, SCH MED, DEPT PSYCHIAT, NEW HAVEN, CT 06510 USA

[3] YALE UNIV, SCH MED, DEPT NEUROANAT, NEW HAVEN, CT 06510 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1986年 / 121卷 / 02期

关键词：

D O I：

10.1016/0014-2999(86)90501-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Continuous release of diazepam from subcutaneously implanted silastic capsules provided significant protection against pentylenetetrazole seizures in rats for up to 3 weeks. However, the degree of protection seen after 3 weeks of exposure to diazepam was significantly less than after 1 h. These data suggest that continuous exposure to constant low levels of diazepam results in the development of partial tolerance which is not sufficient to eliminate significant anticonvulsant effects.

引用

页码：281 / 284

页数：4

共 10 条

[1] TOLERANCE TO THE ANTI-PENTYLENETETRAZOLE EFFECTS OF DIAZEPAM IN THE MOUSE [J].