EFFECTS OF SEX STEROIDS ON IMMUNOGLOBULIN-M PRODUCTION BY EPSTEIN-BARR VIRUS-TRANSFORMED B-CELL LINE SKW6-CL4

被引：9

作者：

MORI, H

SAWAIRI, M

ITOH, N

HANABAYASHI, T

TAMAYA, T

机构：

[1] Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu, 500

来源：

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER | 1991年 / 8卷 / 06期

关键词：

ESTRADIOL; PROGESTERONE; TESTOSTERONE; INTERLEUKIN-6; B-CELL DIFFERENTIATION;

D O I：

10.1007/BF01133023

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The effects of estradiol (E2), progesterone (P), and testosterone (T) on the production of immunoglobulin (Ig) M by Epstein-Barr virus-transformed B-cell line, SKW6-CL4, were investigated. Interleukin 6 (IL-6) induced IgM production by SKW6-CL4 cells in a dose-dependent manner without any significant increase in thymidine incorporation. E2 at concentrations ranging from 10(-10) to 10(-9) M enhanced IL-6-induced IgM production by SKW6-CL4 cells, whereas E2 at a high concentration of 10(-7) M inhibited both the IgM production and the growth of SKW6-CL4 cells. Time-course studies revealed that E2 acts in the early phase of differentiation of SKW6-CL4 cells in response to IL-6. On the other hand, P and T at physiological and superphysiological levels did not influence either the IgM production or the proliferation of SKW6-CI4 cells. These findings suggest a direct immunoregulatory effect of E2 on human B lineage cells and support the concept that E2 may have a role in the pathogenesis of some autoimmune diseases.

引用

页码：329 / 335

页数：7

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