TH1 AND TH2 CD4(+) T-CELLS IN THE PATHOGENESIS OF ORGAN-SPECIFIC AUTOIMMUNE-DISEASES

被引：1085

作者：

LIBLAU, RS ^{[1
]}

SINGER, SM ^{[1
]}

MCDEVITT, HO ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 01期

关键词：

D O I：

10.1016/0167-5699(95)80068-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) T cells play a Key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4(+) T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them.

引用

页码：34 / 38

页数：5

共 42 条

[1] THE 1ST EXTERNAL DOMAIN OF THE NONOBESE DIABETIC MOUSE CLASS-II I-A BETA-CHAIN IS UNIQUE
ACHAORBEA, H
MCDEVITT, HO
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) : 2435 - 2439
[2] INSULIN-DEPENDENT DIABETES IN THE NOD MOUSE MODEL .2. BETA-CELL DESTRUCTION IN AUTOIMMUNE DIABETES IS A TH2 AND NOT A TH1 MEDIATED EVENT
ANDERSON, JT
CORNELIUS, JG
JARPE, AJ
WINTER, WE
PECK, AB
[J]. AUTOIMMUNITY, 1993, 15 (02) : 113 - 122
[3] SURFACE EXPRESSION OF ALPHA-4 INTEGRIN BY CD4 T-CELLS IS REQUIRED FOR THEIR ENTRY INTO BRAIN PARENCHYMA
BARON, JL
MADRI, JA
RUDDLE, NH
HASHIM, G
JANEWAY, CA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (01) : 57 - 68
[4] ISLET-SPECIFIC T-CELL CLONES FROM THE NOD MOUSE RESPOND TO BETA-GRANULE ANTIGEN
BERGMAN, B
HASKINS, K
[J]. DIABETES, 1994, 43 (02) : 197 - 203
[5] INVIVO ROLE OF INTERLEUKIN-4 IN T-CELL TOLERANCE INDUCED BY AQUEOUS PROTEIN ANTIGEN
BURSTEIN, HJ
ABBAS, AK
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) : 457 - 463
[6] ESSENTIAL ROLE FOR INTERFERON-GAMMA AND INTERLEUKIN-6 IN AUTOIMMUNE INSULIN-DEPENDENT DIABETES IN NOD/WEHI MICE
CAMPBELL, IL
KAY, TWH
OXBROW, L
HARRISON, LC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) : 739 - 742
[7] REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS
CHEN, YH
KUCHROO, VK
INOBE, J
HAFLER, DA
WEINER, HL
[J]. SCIENCE, 1994, 265 (5176) : 1237 - 1240
[8] TARGETING AUTOANTIGEN TO B-CELLS PREVENTS THE INDUCTION OF A CELL-MEDIATED AUTOIMMUNE-DISEASE IN RATS
DAY, MJ
TSE, AGD
PUKLAVEC, M
SIMMONDS, SJ
MASON, DW
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (03) : 655 - 659
[9] PREVENTION OF DIABETES IN NOD MICE TREATED WITH ANTIBODY TO MURINE IFN-GAMMA
DEBRAYSACHS, M
CARNAUD, C
BOITARD, C
COHEN, H
GRESSER, I
BEDOSSA, P
BACH, JF
[J]. JOURNAL OF AUTOIMMUNITY, 1991, 4 (02) : 237 - 248
[10] THE INJECTION OF DEAGGREGATED GAMMA-GLOBULINS IN ADULT MICE INDUCES ANTIGEN-SPECIFIC UNRESPONSIVENESS OF T-HELPER TYPE-1 BUT NOT TYPE-2 LYMPHOCYTES
DEWIT, D
VANMECHELEN, M
RYELANDT, M
FIGUEIREDO, AC
ABRAMOWICZ, D
GOLDMAN, M
BAZIN, H
URBAIN, J
LEO, O
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (01) : 9 - 14

← 1 2 3 4 5 →