STUDY OF THE LITHIATION OF 3-SUBSTITUTED ALPHA-CARBOLINES - A NEW ROUTE TO 3,4-DISUBSTITUTED DERIVATIVES

被引：10

作者：

PAPAMICAEL, C ^{[1
]}

DUPAS, G ^{[1
]}

BOURGUIGNON, J ^{[1
]}

QUEGUINER, G ^{[1
]}

机构：

[1] INST NATL SCI APPL ROUEN,CNRS,IRCOF,CHIM ORGAN FINE & HETEROCYCL LAB,F-76131 MONT ST AIGNAN,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)73123-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of new 3-substituted alpha-carbolines is described and these products were subjected to ortho-lithiation experiments. 3-pivalamido and 3-carboxamido derivatives are cleanly lithiated at 4-position. The results are correlated with MNDO calculations. Various 3,4-disubstituted alpha-carbolines are obtained in excellent yields.

引用

页码：4099 / 4102

页数：4

共 11 条

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