STUDY OF THE LITHIATION OF 3-SUBSTITUTED ALPHA-CARBOLINES - A NEW ROUTE TO 3,4-DISUBSTITUTED DERIVATIVES

被引:10
作者
PAPAMICAEL, C [1 ]
DUPAS, G [1 ]
BOURGUIGNON, J [1 ]
QUEGUINER, G [1 ]
机构
[1] INST NATL SCI APPL ROUEN,CNRS,IRCOF,CHIM ORGAN FINE & HETEROCYCL LAB,F-76131 MONT ST AIGNAN,FRANCE
关键词
D O I
10.1016/S0040-4039(00)73123-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of new 3-substituted alpha-carbolines is described and these products were subjected to ortho-lithiation experiments. 3-pivalamido and 3-carboxamido derivatives are cleanly lithiated at 4-position. The results are correlated with MNDO calculations. Various 3,4-disubstituted alpha-carbolines are obtained in excellent yields.
引用
收藏
页码:4099 / 4102
页数:4
相关论文
共 11 条