BUPIVACAINE 0.125-PERCENT IMPROVES CONTINUOUS POSTOPERATIVE EPIDURAL FENTANYL ANALGESIA AFTER ABDOMINAL OR THORACIC-SURGERY

被引:34
作者
BADNER, NH
BHANDARI, R
KOMAR, WE
机构
[1] Department of Anaesthesia, University Hospital, University of Western Ontario, London, N6A 5A5, Ontario
来源
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 1994年 / 41卷 / 05期
关键词
ANESTHETIC TECHNIQUES; EPIDURAL; PAIN; POSTOPERATIVE; ANALGESICS; FENTANYL; ANESTHETICS; LOCAL; BUPIVACAINE;
D O I
10.1007/BF03009860
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The addition of 0.125% and 0.25% bupivacaine to continuous postoperative epidural infusions of fentanyl, in a 10 mu g.mi(-1) concentration, were studied in 39 patients following abdominal or thoracic surgery in prospective, random, double-blind fashion. Patients received an initial bolus of 0.1 ml.kg(-1) of the the study solution and an infusion of 6 ml.hr(-1) which was titrated to maintain analgesia (VAS < 40). Assessments of pain (VAS), pulmonary function (pH, PaCO2), and bowel function (time to flatus or po fluids) were made until the second postoperative morning. There was a difference among the three groups in analgesia (means VAS scores) over time (P < 0.01), with the fentanyl-alone group producing less analgesia than the 0.125% bupivacaine group (P < 0.01). There was no difference in the average infusion rates, postoperative pulmonary function, or bowel function. The incidence of side effects including somnolence, nausea and vomiting, and pruritus was also similar.
引用
收藏
页码:387 / 392
页数:6
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