SUPPRESSING EFFECT OF VANILLIN ON CHROMOSOME-ABERRATIONS THAT OCCUR SPONTANEOUSLY OR ARE INDUCED BY MITOMYCIN-C IN THE GERM-CELL LINE OF DROSOPHILA-MELANOGASTER

被引：17

作者：

DEANDRADE, HHR

SANTOS, JH

GIMMLERLUZ, MC

CORREA, MJF

LEHMANN, M

REGULY, ML

机构：

[1] Laboratorio de Mutagénese, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS

来源：

MUTATION RESEARCH | 1992年 / 279卷 / 04期

关键词：

VANILLIN; ANTICLASTOGENIC EFFECT; RING-X LOSS; DROSOPHILA-MELANOGASTER; MITOMYCIN-C; METHYL METHANESULFONATE;

D O I：

10.1016/0165-1218(92)90245-U

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In order to investigate the anticlastogenic effect of vanillin on ring-X loss, D. melanogaster females exposed to different vanillin concentrations were crossed with non-treated, MMC- or MMS-treated males. The results obtained with this in vivo investigation showed a significant inhibition of vanillin in the frequencies of spontaneous ring-X loss - 59, 56, 38 and 36% - at the different concentrations used. In addition, vanillin treatment caused a significant suppression of MMC-induced ring-X loss. This decrease was observed only in the first 3 days after the interruption of vanillin treatment and at the concentrations of 0.5 and 1% of this flavoring agent. In contrast, vanillin did not show any effect on chromosome loss provoked by MMS. Therefore, the ring-X loss-decreasing effect of vanillin seemed to depend on the quality of DNA lesions and consequently on a specific enzymatic repair process present in the oocytes of D. melanogaster.

引用

页码：281 / 287

页数：7

共 28 条

[1] X-RAY-INDUCED SEX-CHROMOSOME LOSS, WHEN RING-X CHROMOSOME MALES ARE IRRADIATED AND MATED TO FEMALES CARRYING MEI-9, MEI-41 OR MEI-218 [J].

AARON, CS ;

LEIGH, B .

MUTATION RESEARCH, 1981, 82 (02) :381-388

[2] MECHANISMS OF CHROMOSOMAL ABERRATION PRODUCTION .3. CHEMICALS AND IONIZING-RADIATION [J].

BENDER, MA ;

GRIGGS, HG ;

BEDFORD, JS .

MUTATION RESEARCH, 1974, 23 (02) :197-212

[3]

HARTLEY AP, 1980, ENVIRON EXP BOT, V20, P119

[4] SUPPRESSION OF MITOMYCIN-C-INDUCED MICRONUCLEI IN MOUSE BONE-MARROW CELLS BY POST-TREATMENT WITH VANILLIN [J].

INOUYE, T ;

SASAKI, YF ;

IMANISHI, H ;

WATANEBE, M ;

OHTA, T ;

SHIRASU, Y .

MUTATION RESEARCH, 1988, 202 (01) :93-95

[5]

Kada T, 1986, Basic Life Sci, V39, P181

[6] TABLES FOR DETERMINING STATISTICAL SIGNIFICANCE OF MUTATION FREQUENCIES [J].

KASTENBAUM, MA ;

BOWMAN, KO .

MUTATION RESEARCH, 1970, 9 (05) :527-+

[7] THE EFFECTS OF POST-TREATMENTS WITH CAFFEINE DURING S AND G2 ON THE FREQUENCIES OF CHROMOSOMAL-ABERRATIONS INDUCED BY THIOTEPA IN ROOT-TIPS OF VICIA-FABA AND IN HUMAN-LYMPHOCYTES INVITRO [J].

KIHLMAN, BA ;

HANSSON, K ;

ANDERSSON, HC .

MUTATION RESEARCH, 1982, 104 (4-5) :323-330

[8] G2 REPAIR AND THE FORMATION OF CHROMOSOMAL-ABERRATIONS .2. THE EFFECT OF HYDROXYUREA, 5-FLUORODEOXYURIDINE AND CAFFEINE ON STREPTONIGRIN-INDUCED AND 8-ETHOXYCAFFEINE-INDUCED CHROMOSOME-DAMAGE IN VICIA-FABA [J].

KIHLMAN, BA ;

ANDERSSON, HC .

ENVIRONMENTAL AND EXPERIMENTAL BOTANY, 1980, 20 (03) :271-+

[9] ANTIMUTAGENESIS BY FACTORS AFFECTING DNA-REPAIR IN BACTERIA [J].

KURODA, Y ;

INOUE, T .

MUTATION RESEARCH, 1988, 202 (02) :387-391

[10]

Leigh B, 1976, GENETICS BIOLOGY D B, P505

← 1 2 3 →