T-LYMPHOCYTES BEARING THE GAMMA-DELTA T-CELL RECEPTOR IN CUTANEOUS LESIONS OF LANGERHANS CELL HISTIOCYTOSIS

被引：6

作者：

ALAIBAC, M

CHU, AC

机构：

[1] Unit of Dermatology, Royal Postgraduate Medical School, Hammersmith Hospital, London

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1993年 / 21卷 / 05期

关键词：

LANGERHANS CELL HISTIOCYTOSIS (LCH); GAMMA-DELTA T-CELLS; T-CELL RECEPTOR (TCR);

D O I：

10.1002/mpo.2950210507

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to investigate the regional importance of gammadelta T cells in cutaneous lesions of Langerhans' cell histiocytosis. Six cases of Langerhans' cell histiocytosis were investigated by immunohistochemical techniques (alkaline phosphatase-antialkaline phosphatase complex and indirect immunoperoxidase). Increase of gammadelta T cells was observed in 3 cases of Langerhans' cell histiocytosis. In these cases up to 30% of CD3+ cells stained with an anti-TCR gammadelta monoclonal antibodies and in two of them gammadelta T cells showed a marked epidermotropism. In the specimens of the remaining three cases gammadelta T cells were found in an overall percentage of 5% of CD3+ cells, but in two cases a significant increase of epidermal gammadelta T cells was observed. The finding of numerous gammadelta T cells in Langerhans' cell histiocytosis is provocative and supports the suggestion of a functional relationship between gammadelta T cells and LCH cells.

引用

页码：347 / 349

页数：3

共 22 条

[1] IMMUNOCHEMICAL PROOF THAT A NOVEL REARRANGING GENE ENCODES THE T-CELL RECEPTOR-DELTA SUBUNIT
BAND, H
HOCHSTENBACH, F
MCLEAN, J
HATA, S
KRANGEL, MS
BRENNER, MB
[J]. SCIENCE, 1987, 238 (4827) : 682 - 684
[2] BERTI E, 1988, LANGERHANS CELLS, P467
[3] BORN W, 1990, IMMUNOL TODAY, V11, P40
[4] CHU T, 1987, LANCET, V1, P208
[5] IMMUNOENZYMATIC LABELING OF MONOCLONAL-ANTIBODIES USING IMMUNE-COMPLEXES OF ALKALINE-PHOSPHATASE AND MONOCLONAL ANTI-ALKALINE PHOSPHATASE (APAAP COMPLEXES)
CORDELL, JL
FALINI, B
ERBER, WN
GHOSH, AK
ABDULAZIZ, Z
MACDONALD, S
PULFORD, KAF
STEIN, H
MASON, DY
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1984, 32 (02) : 219 - 229
[6] ESTERLY NB, 1985, J AM ACAD DERMATOL, V13, P481
[7] FALINI B, 1989, J IMMUNOL, V143, P2480
[8] Favara B E, 1987, Hematol Oncol Clin North Am, V1, P75
[9] EXPRESSION OF THE GAMMA-DELTA-T-CELL RECEPTOR ON INTESTINAL CD8+ INTRAEPITHELIAL LYMPHOCYTES
GOODMAN, T
LEFRANCOIS, L
[J]. NATURE, 1988, 333 (6176) : 855 - 858
[10] POSSIBLE MECHANISM OF ACTION OF CD1A ANTIGENS
HANAU, D
SCHMITT, DA
BIEBER, T
SCHMITT, D
CAZENAVE, JP
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (05) : 503 - 505

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