REVERSIBLE LOW-MOLECULAR-WEIGHT PROTEINURIA IN PATIENTS WITH DISTAL RENAL TUBULAR-ACIDOSIS

被引：19

作者：

IGARASHI, T

KAWATO, H

KAMOSHITA, S

机构：

[1] Department of Paediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, 113, 7-3-1 Hongo, Bunkyo-ku

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 06期

关键词：

ALPHA-1-MICROGLOBULIN; BETA-2-MICROGLOBULIN; DISTAL RENAL TUBULAR ACIDOSIS; HYPOKALEMIA;

D O I：

10.1007/BF00858629

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Four patients with untreated renal tubular acidosis had a urinary excretion of low-molecular-weight (LMW) proteins which was restored to normal by alkali therapy. Hypokalaemic proximal tubular damage in untreated patients with distal renal tubular acidosis is believed to be the cause of LMW proteinuria. An examination of urinary excretion of LMW proteins is useful for determining hypokalaemic proximal tubular dysfunction, as well as the efficiency of alkali therapy.

引用

页码：593 / 596

页数：4

共 21 条

[1]

Morris R.C., Sebastian A., McSherry E., Renal acidosis, Kidney Int, 1, pp. 322-340, (1972)

[2]

Chan J.C.M., Renal tubular acidosis, J Pediatr, 102, pp. 327-340, (1983)

[3]

Noto A., Ogawa Y., Mori S., Yoshioka M., Kitakaze T., Hori T., Nakamura M., Miyake T., Simple, rapid spectrophotometry of urinary N-acetyl-beta-D-glucosaminidase, with use of a new chromogenic substrate, Clin Chem, 29, pp. 1713-1716, (1983)

[4]

Ekstrom B., Berggard I., Human α1-microglobulin, J Biol Chem, 252, pp. 8048-8057, (1977)

[5]

Evrin P.E., Peterson P.A., Bergard I., Radioimmunoassay of beta 2 microglobulin in human biological fluid, J Clin Invest, 28, pp. 439-443, (1971)

[6]

Strober W., Waldmann T.A., The role of the kidney in the metabolism of plasma proteins, Nephron, 13, pp. 35-66, (1974)

[7]

Wibell L., Karlsson F.A., The urinary excretion of beta 2 microglobulin after the induction of a diuresis. A study in healthy subjects, Nephron, 17, pp. 343-352, (1976)

[8]

Peterson P.A., Evrin P-E, Berggard I., Differentiation of glomerular, tubular, and normal proteinuria: determination of urinary excretion of beta 2 microglobulin, albumin, and total protein, J Clin Invest, 48, pp. 1189-1198, (1969)

[9]

Hall P.W., Vasiljevin M., Beta 2 microglobulin excretion as an index of renal tubular disorders with special reference to endemic Balkan nephropathy, J Lab Clin Med, 81, pp. 897-902, (1973)

[10]

Schardijn G., Statius L.W., Swaak A.J.G., Kager J.C.G.M., Persijn J.P., Urinary beta 2 microglobulin in upper and lower urinary tract infection, Lancet, 1, pp. 805-807, (1979)

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