THE RECEPTORS FOR PROLACTIN AND GROWTH-HORMONE ARE LOCALIZED IN THE SAME REGION OF HUMAN CHROMOSOME-5

被引：55

作者：

ARDEN, KC

BOUTIN, JM

DJIANE, J

KELLY, PA

CAVENEE, WK

机构：

[1] ROYAL VICTORIA HOSP,LUDWIG INST CANC RES,687 PINE AVE W,MONTREAL H3A 1A1,QUEBEC,CANADA

[2] INRA,UNITE ENDOCRINOL MOLEC,F-78350 JOUY EN JOSAS,FRANCE

[3] ROYAL VICTORIA HOSP,MOLEC ENDOCRINOL LAB,MONTREAL H3A 1A1,QUEBEC,CANADA

[4] MCGILL UNIV,MONTREAL H3A 2T5,QUEBEC,CANADA

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 53卷 / 2-3期

关键词：

D O I：

10.1159/000132919

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Prolactin receptor (PRLR) and growth hormone receptor (GHR) are encoded by members of a gene family containing regions of identical sequences. To determine their chromosomal locations. cDNA probes for these genes were used. Analysis of hybridization to several somatic cell hybrids, together with hybridization in situ to melaphase chromosomes, resulted in the assignment of the loci for both receptors to human chromosome 5 in the region p13—p14. Thus, these proteins may be encoded by a cluster of related genes that evolved from a common ancestral gene, in a manner consonant with that of their ligands. © 1990 S. Karger AG, Basel.

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页码：161 / 165

页数：5

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