A DIRECT COMPARISON OF EXTRACTION AND HOMOGENEOUS BINDING CONSTANTS AS PREDICTORS OF EFFICACY IN ALKALI-METAL CATION-TRANSPORT

被引：38

作者：

HERNANDEZ, JC ^{[1
]}

TRAFTON, JE ^{[1
]}

GOKEL, GW ^{[1
]}

机构：

[1] UNIV MIAMI,DEPT CHEM,CORAL GABLES,FL 33124

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 44期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(91)80144-U

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A family of 16 new lipophilic 12-, 15-, and 18-membered ring, ester and amide-sidearmed lariat ethers has been prepared, characterized, and studied. It is found that alkali metal cation transport in a bulk CHCl3 membrane correlates well with both log K(S) determined in CH3OH and with picrate extraction constants determined in the membrane solvent mixture.

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收藏

页码：6269 / 6272

页数：4

相关论文

共 15 条

[1]

Araki T., 1990, LIQUID MEMBRANES CHE

[2] EXPERIMENTAL-METHOD FOR THE DETERMINATION OF CATION BINDING CONSTANTS IN METHANOL USING ION-SELECTIVE ELECTRODE METHODS [J].

ARNOLD, KA ;

GOKEL, GW .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (25) :5015-5016

[3]

BRUENING RL, 1990, CATION BINDING MACRO, P111

[4] LIQUID MEMBRANE SEPARATIONS OF METAL-CATIONS USING MACROCYCLIC CARRIERS [J].

CHRISTENSEN, JJ ;

LAMB, JD ;

BROWN, PR ;

OSCARSON, JL ;

IZATT, RM .

SEPARATION SCIENCE AND TECHNOLOGY, 1981, 16 (09) :1193-1215

[5] EXTRACTION AND TRANSPORT OF ALKALI-METAL SALTS BY CROWN ETHERS AND CRYPTANDS - ESTIMATION OF EXTRACTION CONSTANTS AND THEIR RELATIONSHIP TO TRANSPORT FLUX [J].

FYLES, TM .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1987, 65 (04) :884-891

[6] SYNTHESES OF CALCIUM-SELECTIVE, SUBSTITUTED DIAZA-CROWN ETHERS - A NOVEL, ONE-STEP FORMATION OF BIBRACCHIAL LARIAT ETHERS (BIBLES) [J].

GATTO, VJ ;

GOKEL, GW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (26) :8240-8244

[7] SYNTHESES AND BINDING-PROPERTIES OF BIBRACHIAL LARIAT ETHERS (BIBLES) - SURVEY OF SYNTHETIC METHODS AND CATION SELECTIVITIES [J].

GATTO, VJ ;

ARNOLD, KA ;

VISCARIELLO, AM ;

MILLER, SR ;

MORGAN, CR ;

GOKEL, GW .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (26) :5373-5384

[8] STEROIDAL LARIAT ETHERS - A NEW CLASS OF MACROCYCLES AND THE CRYSTAL-STRUCTURE OF N-(CHOLESTERYLOXYCARBONYL)AZA-15-CROWN-5 [J].

GOKEL, GW ;

HERNANDEZ, JC ;

VISCARIELLO, AM ;

ARNOLD, KA ;

CAMPANA, CF ;

ECHEGOYEN, L ;

FRONCZEK, FR ;

GANDOUR, RD ;

MORGAN, CR ;

TRAFTON, JE ;

MILLER, SR ;

MINGANTI, C ;

EIBAND, D ;

SCHULTZ, RA ;

TAMMINEN, M .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (14) :2963-2968

[9] MACROCYCLE-FACILITATED TRANSPORT OF IONS IN LIQUID MEMBRANE SYSTEMS [J].

IZATT, RM ;

CLARK, GA ;

BRADSHAW, JS ;

LAMB, JD ;

CHRISTENSEN, JJ .

SEPARATION AND PURIFICATION METHODS, 1986, 15 (01) :21-72

[10] SELECTIVE TRANSPORT OF ALKALI-METAL CATIONS THROUGH A LIQUID MEMBRANE BY MACROBICYCLIC CARRIERS [J].

KIRCH, M ;

LEHN, JM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1975, 14 (08) :555-556