HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY DETERMINATION OF DOXORUBICIN AND DAUNORUBICIN IN PLASMA USING UV DETECTION AND COLUMN SWITCHING

被引：14

作者：

MIKAN, A

LANAO, JM

LOPEZ, FG

HURLE, ADG

机构：

[1] UNIV SALAMANCA,FAC FARM,AVDA CAMPO CHARRO S-N,E-37007 SALAMANCA,SPAIN

[2] JZD AGROKOMBINAT,CS-76315 SLUSOVICE,CZECHOSLOVAKIA

来源：

BIOMEDICAL CHROMATOGRAPHY | 1990年 / 4卷 / 04期

关键词：

D O I：

10.1002/bmc.1130040408

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for the determination of doxorubicin and daunorubicin in plasma is described. The plasma is injected directly into a loop column and then washed with water. After switching the injection valve, the sample is separated on a phenyl column using detection at 254 nm. The detection limit is 10 ng/mL, the coefficient of variation is 7% for 100 ng/mL of doxorubicin and 4% for 200 ng/mL of daunorubicin. Copyright © 1990 John Wiley & Sons, Ltd.

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页码：154 / 156

页数：3

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