Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa

被引：71

作者：

Bagad, Ashish Subhash ^{[1
]}

Joseph, Joshua Allan ^{[1
]}

Bhaskaran, Natarajan ^{[1
]}

Agarwal, Amit ^{[1
]}

机构：

[1] R&D Ctr Nat Remedies, Plot 5B,Veerasandra Indl Area 19th KM Stone, Bangalore 560100, Karnataka, India

来源：

ADVANCES IN PHARMACOLOGICAL SCIENCES | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/805756

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Curcuma longa is widely known for its anti-inflammatory activity in traditional system of medicine for centuries and has been scientifically validated extensively. The present study was conducted to evaluate the anti-inflammatory activity of curcuminoids and oil-free aqueous extract (COFAE) of C. longa and compare it with that of curcuminoids and turmerones (volatile oil), the bioactive components of C. longa that are proven for the anti-inflammatory potential. The activity against inflammation was evaluated in xylene-induced ear edema, cotton pellet granuloma models in albino Swiss mice and albino Wistar rats, respectively. The results showed that COFAE of C. longa at three dose levels significantly (P <= 0.05) inhibited inflammation in both models, as evidenced by reduction in ear weight and decrease in wet as well as dry weights of cotton pellets, when compared to the vehicle control. The COFAE of C. longa showed considerable anti-inflammatory effects against acute and chronic inflammation and the effects were comparable to those of curcuminoids and turmerones.

引用

页数：7

共 54 条

[1]

Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages [J].

Abe, Y ;

Hashimoto, S ;

Horie, T .

PHARMACOLOGICAL RESEARCH, 1999, 39 (01) :41-47

[2]

Aggarwal BB, 2003, ANTICANCER RES, V23, P363

[3]

[Anonymous], 1996, COMPLEMENTARY ALTERN, V3, P3

[4]

[Anonymous], 2012, US COMPL ALT MED US

[5]

Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts [J].

Atta, AH ;

Alkofahi, A .

JOURNAL OF ETHNOPHARMACOLOGY, 1998, 60 (02) :117-124

[6]

PROTECTIVE ROLE OF AQUEOUS TURMERIC EXTRACT AGAINST MUTAGENICITY OF DIRECT-ACTING CARCINOGENS AS WELL AS BENZO[A]PYRENE-INDUCED GENOTOXICITY AND CARCINOGENICITY [J].

AZUINE, MA ;

KAYAL, JJ ;

BHIDE, SV .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1992, 118 (06) :447-452

[7]

Badgujar VB, 2009, ASIAN J PHARM CLIN R, V2, P63

[8]

Beg Sarwar, 2011, Pharmacogn Rev, V5, P120, DOI 10.4103/0973-7847.91102

[9]

MODULATION OF MOUSE EAR EDEMA BY CYCLOOXYGENASE AND LIPOXYGENASE INHIBITORS AND OTHER PHARMACOLOGICAL AGENTS [J].

CARLSON, RP ;

ONEILLDAVIS, L ;

CHANG, J ;

LEWIS, AJ .

AGENTS AND ACTIONS, 1985, 17 (02) :197-204

[10]

Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction [J].

Chandrasekaran, Chinampudur V. ;

Sundarajan, Kannan ;

Edwin, Jothie R. ;

Gururaja, Giligar M. ;

Mundkinajeddu, Deepak ;

Agarwal, Amit .

PHARMACOGNOSY RESEARCH, 2013, 5 (02) :71-79

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