HUMAN TRYPTOPHAN OXYGENASE LOCALIZED TO 4Q31 - POSSIBLE IMPLICATIONS FOR ALCOHOLISM AND OTHER BEHAVIORAL-DISORDERS

被引：23

作者：

COMINGS, DE ^{[1
]}

MUHLEMAN, D ^{[1
]}

DIETZ, GW ^{[1
]}

DONLON, T ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,STANFORD,CA 94305

来源：

GENOMICS | 1991年 / 9卷 / 02期

关键词：

D O I：

10.1016/0888-7543(91)90257-F

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A human tryptophan oxygenase clone was isolated by screening a liver cDNA library with a rat tryptophan oxygenase cDNA clone. Analysis showed extensive homology between the rat and the human DNA and protein sequences. The combined use of cell hybrids and in situ hydridization indicated that human tryptophan oxygenase was localized to chromosome band 4q31. The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism. © 1991.

引用

页码：301 / 308

页数：8

共 53 条

[1] ASTON CE, 1990, AM J HUM GENET, V46, P879
[2] LIVER TRYPTOPHAN-PYRROLASE - A MAJOR DETERMINANT OF THE LOWER BRAIN 5-HYDROXYTRYPTAMINE CONCENTRATION IN ALCOHOL-PREFERRING C57BL MICE
BADAWY, AAB
MORGAN, CJ
LANE, J
DHALIWAL, K
BRADLEY, DM
[J]. BIOCHEMICAL JOURNAL, 1989, 264 (02) : 597 - 599
[3] PLATELET SEROTONIN DECREASE IN ALCOHOLIC PATIENTS
BAILLY, D
VIGNAU, J
LAUTH, B
RACADOT, N
BEUSCART, R
SERVANT, D
PARQUET, PJ
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1990, 81 (01) : 68 - 72
[4] BALLENGER JC, 1979, ARCH GEN PSYCHIAT, V36, P224
[5] DEPRESSION, SUICIDE, AND AGGRESSION IN ALCOHOLICS AND THEIR RELATIONSHIP TO PLASMA AMINO-ACIDS
BRANCHEY, L
BRANCHEY, M
SHAW, S
LIEBER, CS
[J]. PSYCHIATRY RESEARCH, 1984, 12 (03) : 219 - 226
[6] BROWN GL, 1982, AM J PSYCHIAT, V139, P741
[7] BIOGENIC-AMINE METABOLISM IN TOURETTE SYNDROME
BUTLER, IJ
KOSLOW, SH
SEIFERT, WE
CAPRIOLI, RM
SINGER, HS
[J]. ANNALS OF NEUROLOGY, 1979, 6 (01) : 37 - 39
[8] BUYDENSBRANCHEY L, 1989, ARCH GEN PSYCHIAT, V46, P231
[9] CHASE TN, 1973, ANNU REV PHARMACOL, V18, P181
[10] CENTRAL BIOGENIC-AMINE METABOLISM IN CHILDREN WITH THE SYNDROME OF CHRONIC MULTIPLE TICS OF GILLES-DE-LA-TOURETTE - NOREPINEPHRINE, SEROTONIN, AND DOPAMINE
COHEN, DJ
SHAYWITZ, BA
YOUNG, JG
CARBONARI, CM
NATHANSON, JA
LIEBERMAN, D
BOWERS, MB
MAAS, JW
[J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1979, 18 (02) : 320 - 341

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