FACIAL-NERVE TRANSECTION CAUSES EXPANSION OF MYELIN AUTOREACTIVE T-CELLS IN REGIONAL LYMPH-NODES AND T-CELL HOMING TO THE FACIAL NUCLEUS

被引:76
作者
OLSSON, T
DIENER, P
LJUNGDAHL, A
HOJEBERG, B
VANDERMEIDE, PH
KRISTENSSON, K
机构
[1] Department of Neurology, Karolinska Institutet, Huddinge Hospital, Stockholm
[2] Institute of Applied Radiobiology and Immunology, TNO, Rijswijk
[3] Clinical Research Center, Huddinge Hospital, Stockholm
关键词
INTERFERON-GAMMA; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN BASIC PROTEIN;
D O I
10.3109/08916939209001912
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Nervous tissue expression of immunological signal and recognition molecules, as well as lymphoid tissue immune responses after facial nerve trauma was studied in male rats of the Lewis and Brown Norway (BN) strains. In both rat strains nerve transection caused within four days the appearance of IFN-gamma-like immunoreactivity in the cytoplasm of axotomized motor neurons and an induction of MHC class I and II, and CD4 molecules on surrounding glial cells to a similar extent. T lymphocytes also infiltrated the facial nuclei ipsilateral to the axotomy in all animals. The number of autoreactive T cells in superficial cervical lymph nodes, which in response to whole myelin or peptides of myelin basic protein (MBP) secreted IFN-gamma-increased markedly after axotomy. This response was more conspicuous in Lewis rats, which are susceptible to experimental allergic encephalomyelitis (EAE), than in BN rats, which are EAE resistant. A proportion of the axotomized Lewis rats also developed widespread perivascular infiltration of mononuclear cells in the CNS, reminiscent of EAE. Hypothetically, a strong expansion of myelin autoreactive IFN-gamma producing T cells secondary to nerve trauma may have immunopathological consequences in genetically predisposed individuals. It is also possible that myelin reactive T cells, whether recruited to the lesioned nerve, could have impact on macrophage function during Wallerian degeneration in the distal stump.
引用
收藏
页码:117 / 126
页数:10
相关论文
共 60 条
[1]  
Torvik A., Central chromatolysis and the axon reaction. A reappraisal, Neuropathol Appl Neurobiol, 2, pp. 423-432, (1976)
[2]  
Sjostrand J., Proliferative changes in glial cells during nerve regeneration, Z Zellforsch, 68, (1965)
[3]  
Cova J.L., Aldskogius H., Effect of axotomy on perineuronal glial cells in the hypoglossal and dorsal motor vagal nuclei of the rat, Exp Neural, 93, pp. 662-667, (1986)
[4]  
Streit W.J., Graeber M.B., Kreutzberg G.W., Expression of la antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury, Exp Neural, 105, pp. 115-126, (1989)
[5]  
Graeber M.B., Kreutzberg G.W., Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons, J Neurocytol, 15, pp. 363-373, (1986)
[6]  
Stoll G., Griffin J.W., Li G.Y., Trapp B.D., Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin breakdown, J Neurocytol, 18, pp. 671-683, (1989)
[7]  
Lunn E.R., Perry V.H., Brown M.C., Rosen H., Gordon S., Absence of Wallerian degeneration does not hinder regeneration in peripheral nerve, Eur J Neurosci, 1, pp. 27-33, (1989)
[8]  
Olsson T., Ljungdahl A., Kristensson K., Maehlen J., Klareskog L., Holmdahl R., Gamma-interferon-like immunoreactivity in axotomized rat motor neurons, J Neurosci, 89, pp. 3870-3876, (1989)
[9]  
Kiefer R., Haas C.A., Kreutzberg G.W., Gamma interferon-like immunoreactive material in rat neurons: Evidence against a close relationship to gamma interferon, Neurosci, 45, pp. 551-560, (1991)
[10]  
Bazan J.F., Neuropoietic cytokines in the hematopoietic fold, Neuron, 7, pp. 197-208, (1991)