ISOLATION OF ANTIRHINOVIRAL SESQUITERPENES FROM GINGER (ZINGIBER-OFFICINALE)

被引：80

作者：

DENYER, CV ^{[1
]}

JACKSON, P ^{[1
]}

LOAKES, DM ^{[1
]}

ELLIS, MR ^{[1
]}

YOUNG, DAB ^{[1
]}

机构：

[1] WELLCOME RES LABS,DEPT MOLEC SCI,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 05期

关键词：

D O I：

10.1021/np50107a017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The dried rhizomes of Indonesian ginger, Zingiber officinale, were investigated for antirhinoviral activity in the plaque reduction rest. Fractionation by solvent extraction, solvent partition, and repeated chromatography guided by bioassay, allowed the isolation of several sesquiterpenes with antirhinoviral activity. The most active of these was beta-sesquiphellandrene [2] with an IC50 of 0.44 mu M vs. rhinovirus IB in vitro.

引用

页码：658 / 662

页数：5

共 21 条

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