CRYSTAL-STATE CONFORMATION OF HOMO-OLIGOMERS OF ALPHA-AMINOISOBUTYRIC-ACID - MOLECULAR AND CRYSTAL-STRUCTURE OF PBRBZ-(AIB)6-OME

被引：14

作者：

DIBLASIO, B

SANTINI, A

PAVONE, V

PEDONE, C

BENEDETTI, E

MORETTO, V

CRISMA, M

TONIOLO, C

机构：

[1] NAPLES UNIV,DEPT CHEM,I-80134 NAPLES,ITALY

[2] UNIV PADUA,CNR,DEPT ORGAN CHEM,BIOPOLYMER RES CTR,I-35131 PADUA,ITALY

来源：

STRUCTURAL CHEMISTRY | 1991年 / 2卷 / 05期

关键词：

D O I：

10.1007/BF00672885

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic, terminally blocked homohexapeptide from alpha-aminoisobutyric acid has been examined by single-crystal X-ray diffraction and the structure refined to R = 0.047. The compound is folded into almost two turns of a 3(10)-helix, stabilized by four consecutive intramolecular N-H. . . .O = C H-bonds. An asymmetric covalent geometry for the alpha-aminoisobutyric acid residues, known to be responsible for the onset of the 3(10)-helix in homopeptides from this C-alpha,alpha-dialkylated alpha-aminoacid on the basis of a theoretrical conformational analysis, has been experimentally found also in this structure.

引用

页码：523 / 527

页数：5

共 22 条

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