COMPARISONS BETWEEN THE EFFECTS OF 5-HT AND DL-FENFLURAMINE ON FOOD-INTAKE AND GASTRIC-EMPTYING IN THE RAT

被引：33

作者：

FRANCIS, J

CRITCHLEY, D

DOURISH, CT

COOPER, SJ

机构：

[1] UNIV BIRMINGHAM,SCH PSYCHOL,PSYCHOPHARMACOL LAB,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] WYETH RES UK LTD,DEPT NEUROPHARMACOL,MAIDENHEAD SL6 0PH,BERKS,ENGLAND

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 50卷 / 04期

关键词：

5-HT; DL-FENFLURAMINE; FOOD INTAKE; GASTRIC EMPTYING; RAT;

D O I：

10.1016/0091-3057(94)00344-0

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

5-Hydroxytryptamine (5-HT) dose-dependently increased gastric emptying in rats, whereas DL-fenfluramine produced a biphasic dose response curve for gastric emptying. Thus, fenfluramine increased gastric emptying at a dose of 0.1 mg/kg but decreased it at doses of 1 and 3 mg/kg. Both 5-HT and DL-fenfluramine produced significant decreases in food intake. As 5-HT produced opposing effects on gastric emptying and food intake, it appears that the anorectic effect of 5-HT may not depend on changes in the rate of gastric emptying. In contrast, doses of DL-fenfluramine that decreased feeding also decreased gastric emptying, which suggests that reduced food intake may at least partly result from decreased gastric emptying. Taken together, these results suggest that the effects of 5-HT and DL-fenfluramine on feeding and gastric emptying may be mediated by different mechanisms.

引用

页码：581 / 585

页数：5

共 20 条

[1] EFFECTS OF DL-FENFLURAMINE AND XYLAMIDINE ON GASTRIC-EMPTYING OF MAINTENANCE DIET IN FREELY FEEDING RATS [J].