PHOTOSENSITIZED FORMATION OF 8-HYDROXY-2'-DEOXYGUANOSINE IN SALMON TESTES DNA BY FUROCOUMARIN HYDROPEROXIDES - A NOVEL, INTERCALATING PHOTO-FENTON REAGENT FOR OXIDATIVE DNA-DAMAGE

被引：40

作者：

ADAM, W

CADET, J

DALLACQUA, F

EPE, B

RAMAIAH, D

SAHAMOLLER, CR

机构：

[1] CEA,DEPT RECH FONDAMENTALE MAT CONDENSEE,SESAM LES ACIDES NUCL,GRENOBLE,FRANCE

[2] UNIV PADUA,DEPT PHARMACEUT SCI,PADUA,ITALY

[3] UNIV WURZBURG,INST PHARMAKOL & TOXIKOL,W-8700 WURZBURG,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 01期

关键词：

DNA OXIDATION; FUROCOUMARINS; HYDROPEROXIDES; 8-HYDROXY-2'-DEOXYGUANOSINE; HYDROXYL RADICALS;

D O I：

10.1002/anie.199501071

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Furocoumarin hydroperoxides such as 1 are novel photochemical sources of hydroxyl radicals; in salmon testes DNA they form the mutagenic oxidation product 8‐hydroxy‐2′‐deoxyguanosine 2 in up to 1.8% yield on UVA irradiation (λ = 350 nm). (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：107 / 110

页数：4

共 39 条

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