SYNTHESIS OF PYRRYL ARYL SULFONES TARGETED AT THE HIV-1 REVERSE-TRANSCRIPTASE

Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1, 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Some structure-activity relationships are discussed also in comparison with the known NPPS (2-nitorphenyl phenyl sulfone).