A CONCISE SYNTHESIS OF THE ANTIFUNGAL AGENT (+)-PREUSSIN

被引：87

作者：

OVERHAND, M

HECHT, SM

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

[2] UNIV VIRGINIA,DEPT BIOL,CHARLOTTESVILLE,VA 22901

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 17期

关键词：

D O I：

10.1021/jo00096a007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antifungal agent (+)-preussin (1) was synthesized in five efficient transformations from t-Boc-(S)-phenylalanine. The key step involved the Hg(II)-mediated ring closure of ynone 4, a 5-endo-dig process.

引用

页码：4721 / 4722

页数：2

共 15 条

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