SOLITARY FIBROUS TUMORS OF SOFT-TISSUE - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 12 CASES

被引:277
作者
SUSTER, S
NASCIMENTO, AG
MIETTINEN, M
SICKEL, JZ
MORAN, CA
机构
[1] MT SINAI MED CTR,DEPT PATHOL & LAB MED,MIAMI,FL
[2] UNIV MIAMI,SCH MED,MIAMI,FL
[3] MAYO CLIN,ROCHESTER,MN
[4] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,PHILADELPHIA,PA 19107
[5] UNIV ROCHESTER,MED CTR,ROCHESTER,NY 14642
[6] ARMED FORCES INST PATHOL,WASHINGTON,DC 20306
关键词
SOLITARY FIBROUS TUMOR; FIBROUS MESOTHELIOMA; CD34; DENDRITIC CELLS; SPINDLE CELL TUMORS;
D O I
10.1097/00000478-199511000-00005
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We describe 12 cases of primary soft tissue neoplasms that showed the histologic and immunohistochemical features of solitary fibrous tumors of serosal surfaces (solitary fibrous mesothelioma, submesothelial fibroma). Nine patients were women and three were men whose ages ranged from 28 to 83 years. Seven lesions were located in the head and neck region, and the remainder were located in the back, buttock, perineum, and groin. The lesions measured from 1 to 6 cm in greatest diameter and presented grossly as well-circumscribed, unencapsulated, soft to rubbery tissue masses, Histologically they were characterized by a proliferation of spindle cells exhibiting a variety of growth patterns, including storiform, herringbone, neural with wavy nuclei, and hemangiopericytic admired with areas of sclerosis. In two cases the lesions showed areas of increased cellularity with occasionally scattered mitotic figures. Three cases were located adjacent to a major salivary gland; in one, entrapment of normal salivary gland acini and ducts could be observed at the edges of the lesion. Immunohistochemical studies showed positive staining of the spindle cells with CD34 (anti-HPCA-1) and vimentin antibodies and negative staining with keratin, actin, desmin, S-100 protein, collagen type IV, and factor VIII related antigen. Follow-up from 6 months to 12 years has shown no evidence of recurrence or metastasis in any of our patients. Solitary fibrous tumors appear to represent ubiquitous mesenchymal neoplasms that may not be necessarily restricted to serosal surfaces. Identification of these lesions is of importance to avoid misdiagnosis with other more aggressive conditions in soft tissue locations.
引用
收藏
页码:1257 / 1266
页数:10
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