MAPPING OF HUMAN AND MURINE GENES FOR LATENT TGF-BETA BINDING PROTEIN-2 (LTBP2)

被引：22

作者：

LI, X

YIN, W

PEREZJURADO, L

BONADIO, J

FRANCKE, U

机构：

[1] STANFORD UNIV,MED CTR,BECKMAN CTR,HOWARD HUGHES MED INST,STANFORD,CA 94305

[2] STANFORD UNIV,MED CTR,DEPT GENET,STANFORD,CA 94305

[3] STANFORD UNIV,MED CTR,DEPT PEDIAT,STANFORD,CA 94305

[4] UNIV MICHIGAN,DEPT PATHOL,ANN ARBOR,MI 48109

来源：

MAMMALIAN GENOME | 1995年 / 6卷 / 01期

关键词：

D O I：

10.1007/BF00350892

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel gene, isolated because of structural similarities to fibrillin, was called LTBP2 when its 4.6-kb transcript was found to encode a protein sequence related to the latent TGF-beta binding protein (LTBP1), which is encoded on human chromosome (Chr) 2, region p12-q22. We have assigned the human and murine LTBP2 loci to regions of conserved synteny on human Chr 11 and mouse Chr 19. By PCR analysis of somatic cell hybrid DNA and fluorescence in situ hybridization, LTBP2 was mapped to human Chr band 11q12 and Ltbp2 to mouse Chr band 19B. Differences between inbred strains were discovered by single-strand conformation analysis of PCR products from the 3' untranslated region. Analysis of BXD and AKXL recombinant inbred strains have placed Ltbp2 between D19Rp19 and Ly10 on proximal mouse Chr 19.

引用

页码：42 / 45

页数：4

共 24 条

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