SYNTHESIS AND C-13 NMR OF (TRIFLUOROMETHYL)HYDROXYPYRAZOLES

被引：54

作者：

LEE, LF

SCHLEPPNIK, FM

SCHNEIDER, RW

CAMPBELL, DH

机构：

[1] Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, St Louis, Missouri

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 02期

关键词：

D O I：

10.1002/jhet.5570270224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of ethyl 4,4,4‐trifluoroacetoacetate with methylhydrazine produced not only the previously reported 5‐hydroxy‐3‐(trifluoromethyl)pyrazole 1 but also its unknown isomer the 3‐hydroxy‐5‐(trifluoromethyl)pyrazole 4. The structure assignments are established based on 13C nmr spectra. Compound 1 was converted to 5‐chloro‐3‐(trifluoromethyl)pyrazolecarboxylic acid 3 in two steps. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：243 / 245

页数：3