INEFFECTIVENESS AND COMPARATIVE PATHOGENICITY OF ATTENUATED RABIES VIRUS-VACCINES FOR THE STRIPED SKUNK (MEPHITIS-MEPHITIS)

被引：56

作者：

RUPPRECHT, CE

CHARLTON, KM

ARTOIS, M

CASEY, GA

WEBSTER, WA

CAMPBELL, JB

LAWSON, KF

SCHNEIDER, LG

机构：

[1] AGR CANADA, ANIM DIS RES INST, NEPEAN K2H 8P9, ONTARIO, CANADA

[2] UNIV TORONTO, FAC MED, DEPT MICROBIOL, TORONTO M5S 1A8, ONTARIO, CANADA

[3] CONNAUGHT LABS LTD, N YORK M2R 3T4, ONTARIO, CANADA

[4] WHO, COLLABORATING CTR RABIES SURVEILLANCE & RES, TUBINGEN, GERMANY

[5] CTR NATL ETUD VET & ALIMENTAIRES, ETUD RAGE & PATHOL ANIM SAUVAGES LAB, F-54220 MALZEVILLE, FRANCE

来源：

JOURNAL OF WILDLIFE DISEASES | 1990年 / 26卷 / 01期

关键词：

D O I：

10.7589/0090-3558-26.1.99

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Three attenuated rabies virus vaccines (SAD-B19, ERA/BHK-21, AZA 2) were compared for efficacy and safety in the striped skunk (Mephitis mephitis) by the oral and intranasal routes. The SAD-B19 and ERA/BHK-21 vaccines were given orally; all three vaccines were given intranasally. Oral administration of SAD-B19 and ERA/BHK-21 vaccines induced neither seroconversion nor significant protection against rabies challenge. One skunk which consumed a SAD-B19 vaccine-laden bait succumbed to vaccine-induced rabies. Intranasal instillation of the three vaccines resulted in the deaths of two of six (AZA 2), three of six (ERA/BHK-21) and six of six (SAD-B19) skunks.

引用

页码：99 / 102

页数：4

共 15 条

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