INHIBITION OF THE COMPLEMENT CASCADE BY THE MAJOR SECRETORY PROTEIN OF VACCINIA VIRUS

被引：284

作者：

KOTWAL, GJ

ISAACS, SN

MCKENZIE, R

FRANK, MM

MOSS, B

机构：

[1] NIAID,VIRAL DIS LAB,BETHESDA,MD 20892

[2] NIAID,CLIN INVEST LAB,BETHESDA,MD 20892

来源：

SCIENCE | 1990年 / 250卷 / 4982期

关键词：

D O I：

10.1126/science.2237434

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.

引用

页码：827 / 830

页数：4

共 27 条

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