CLINICAL AND LABORATORY FEATURES OF TYPE-1 DIABETIC CHILDREN AT THE TIME OF DIAGNOSIS

被引：64

作者：

LEVYMARCHAL, C

PAPOZ, L

DEBEAUFORT, C

DOUTREIX, J

FROMENT, V

VOIRIN, J

CZERNICHOW, P

机构：

[1] Department of Diabetology, Robert Debré Hospital, Paris

[2] INSERM Unit 21, Villejuif

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 03期

关键词：

INCIDENCE; TYPE-1; DIABETES; CHILDREN;

D O I：

10.1111/j.1464-5491.1992.tb01777.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The French incidence study has registered all new cases of Type 1 diabetic children under 20 years of age, from a population of 2.32 million, in an exhaustive and prospective manner. Three hundred and forty cases were identified between 1 January 1988 and 31 December 1989, yielding a mean annual incidence rate 7.3 per 10(5). The lowest rate was observed in the youngest age group (0-4 yr: 4.1 per 10(5)) and the highest around pubertal development (10-14 yr: 11.5 per 10(5)). Details of the previous personal and family history, and the clinical and biological pictures of the disease at diagnosis were recorded. Almost 8 per cent of the children had a first-degree relative with Type 1 diabetes. Polyuria, weight loss, fatigue and abdominal pain were the most frequently reported symptoms, which were of median duration 4.4 months. Mean weight loss before diagnosis was 9.4 +/- 6.8 (+/- SD) % of body weight and was not significantly related to age. Ketonuria was detected in 83.8 per cent and acidosis (total CO2 less-than-or-equal-to 18 mmol l-1, if measured) in 48 per cent of the cases. Ketonuria and acidosis were significantly more frequent in the younger age group than in the rest of the group (p < 0.001).

引用

页码：279 / 284

页数：6

共 29 条

[1]

Reunanen A., Akerblom HK, Kaar ML., Prevalence and ten‐year incidence of insulin‐dependent diabetes mellitus in children and adolescents in Finland, Acta Paediatr Scand, 71, pp. 893-899, (1982)

[2]

Dahlquist G., Gustavsson KH, Holmgren G., Hagglof B., Larsson Y., Nilsson KO, Et al., The incidence of diabetes mellitus in Swedish children 0–14 years of age. A prospective study 1971–1980, Acta Paediatr Scand, 71, pp. 7-14, (1982)

[3]

Joner G., Sovik O., Incidence, age at onset and seasonal variation of diabetes mellitus in Norwegian children, 1973–77, Acta Paediatr Scand, 70, pp. 329-335, (1981)

[4]

Green A., Andersen PK., Epidemiological studies of diabetes mellitus in Denmark, 3. Clinical characteristics and incidence among males aged 0 to 19 years, Diabetologia, 25, pp. 226-230, (1983)

[5]

Patterson CC, Thorogood M., Smith PG, Heasmann MA, Clarke JR, Mann JJ., Epidemiology of Type 1 (insulin‐dependent) diabetes in Scotland 1968–1976: evidence of increasing incidence, Diabetologia, 24, pp. 238-243, (1983)

[6]

Bingley PG, Gale EAM., Incidence of diabetes mellitus in England: a study in the Oxford region, 1985–6, Br Med J, 298, pp. 558-560, (1989)

[7]

(1980)

[8]

Levy-Marchal C., Papoz L., de Beaufort C., Doutreix J., Froment V., Voirin J., Et al., Incidence of Type 1 (insulin‐dependent) diabetes mellitus in France, Diabetologia, 33, pp. 465-469, (1990)

[9]

Sempe M., Pedron G., Roy-Pernot M-P., Auxologie. Méthode et séquences, pp. 44-45, (1979)

[10]

Rewers M., Laporte RE, Walczak M., Dmochowski K., Bogaczynska E., Apparent epidemic of insulin‐dependent diabetes mellitus in midwestern Poland, Diabetes, 36, pp. 106-113, (1987)

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