ADIPOSE-TISSUE AND MUSCLE VOLUME DETERMINATION BY COMPUTED-TOMOGRAPHY IN ACROMEGALY, BEFORE AND 1 YEAR AFTER ADENOMECTOMY

The adipose tissue volume, skeletal muscle and skin volume and visceral organ volume were determined using the multiscan CT (computed tomography) technique in 15 patients with acromegaly. The examinations were performed before treatment and 1 year after transsphenoidal adenectomy. The mean body weight did not change significantly after treatment; 91.3 kg and 92.3 kg pre and postoperatively in men and 66.7 kg and 65.9 kg in women respectively. The total adipose tissue volume increased by 7.1 l (59.2%, P < 0.01) in the male group and 3-9 l (20.3%, P < 0.05) in the female group. Muscle and skin mass and visceral organ mass decreased significantly after treatment. The muscle and skin mass decreased by 3.6 l (-7.4%, P < 0.01) in males and by 3.2 l in females (-11.5%, P < 0.02). The corresponding decrease in visceral organ mass was 1.5 l (-17.0%, P < 0.01) in males and 1.0 l (15.4%, P < 0.05) in females respectively. On average, the fractions of adipose tissue in the subcutaneous trunk and the intra-abdominal depots increased after treatment, while the fractions of adipose tissue in the limbs and the head and neck region decreased. The change in adipose tissue distribution pattern reached significance (P < 0.005) in men only.