PHARMACOKINETICS OF LIGNOCAINE IN CHILDREN AFTER INFILTRATION FOR CLEFT-PALATE SURGERY

被引：5

作者：

MICHAEL, S ^{[1
]}

BARKER, I ^{[1
]}

HENDERSON, P ^{[1
]}

GRIFFITHS, RW ^{[1
]}

REILLY, CS ^{[1
]}

机构：

[1] CHILDRENS HOSP,SHEFFIELD S10 2TH,S YORKSHIRE,ENGLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1992年 / 69卷 / 06期

关键词：

ANESTHESIA; PEDIATRIC; ANESTHETIC TECHNIQUES; LOCAL INFILTRATION; ANESTHETICS; LOCAL; LIGNOCAINE; PHARMACOKINETICS;

D O I：

10.1093/bja/69.6.577

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We ha ve studied the pharmacokinetics of lignocaine in children after local infiltration for cleft palate surgery. After induction of anaesthesia, lignocaine 2.5 mg kg-1 with adrenaline 1:200 000 was injected into the palate. Blood samples were collected before and at 2, 5, 10, 15, 20, 30, 60 and 120 min after infiltration. Plasma concentrations of lignocaine were measured by a gas-liquid chromatographic technique. There were no signs of systemic toxicity on routine monitoring of the patients and the peak plasma concentrations were less than the accepted toxic values. Mean half-life was 72.9 (SEM 9.9) min, similar to that found previously in adults and children. However differences in mean clearance (24.6 (2.04) ml kg-1 min-1) and volume of distribution (0.80 (0.07) litre kg-1) were found between this and previous studies.

引用

页码：577 / 579

页数：3

共 19 条

[1] BLOOD-CONCENTRATION OF LIDOCAINE AFTER SPINAL-ANESTHESIA USING LIDOCAINE AND LIDOCAINE WITH ADRENALINE [J].