SYNTHESIS AND MONOAMINE-OXIDASE INHIBITORY ACTIVITY OF 3-SUBSTITUTED 5H-INDENO[1,2-C]PYRIDAZINES

被引：29

作者：

KNEUBUHLER, S

CARTA, V

ALTOMARE, C

CAROTTI, A

TESTA, B

机构：

[1] UNIV LAUSANNE,ECOLE PHARM,INST CHIM THERAPEUT,CH-1015 LAUSANNE,SWITZERLAND

[2] UNIV BARI,DIPARTIMENTO FARMACOCHIM,I-70126 BARI,ITALY

来源：

HELVETICA CHIMICA ACTA | 1993年 / 76卷 / 05期

关键词：

D O I：

10.1002/hlca.19930760514

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The one-pot synthesis of nine 5H-indeno[1,2-c]pyridazines is described. These compounds are shown to be potent, reversible inhibitors of monoamine oxidase B (MAO-B) with little or no effect on monoamine oxidase A (MAO-A). Qualitative structure-activity relations indicate that the MAO-B inhibitory activity is strongly influenced by electronic and bulk properties of substituents.

引用

页码：1956 / 1963

页数：8

共 26 条

[1] REDUCTION OF TOSYLHYDRAZONES AND OF ACYL TOSYLHYDRAZIDES [J].