THYMOCYTE PROGENITORS IN AGING

被引：10

作者：

GLOBERSON, A

机构：

[1] Department of Cell Biology, Weizmann Institute of Science, Rehovot

来源：

IMMUNOLOGY LETTERS | 1994年 / 40卷 / 03期

关键词：

AGING; BONE MARROW; FETAL THYMUS; LYMPHOHEMATOPOIETIC CELLS; THYMOCYTE PROGENITORS; T LYMPHOCYTES;

D O I：

10.1016/0165-2478(94)00059-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of ageing on thymocyte progenitors in the bone marrow was studied in an in vitro experimental model that permits T lymphocyte development. The model is based on co-culture of BM cells from young and old mice with lymphoid depleted fetal thymus explants. We applied different strategies of thymic colonization, including competitive colonization by BM cells from different donor age groups and MHC backgrounds. Our data reveal intrinsic changes in the BM that lead to manifestation of immunosenescence in the T lymphocyte compartment.

引用

页码：219 / 224

页数：6

共 34 条

[1]

BRILL S, 1988, ISRAEL J MED SCI, V24, P732

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