METACARPOPHALANGEAL PATTERN PROFILE ANALYSIS IN BRACHMANN-DELANGE SYNDROME

被引：6

作者：

BUTLER, MG

DAHIR, GA

GALE, DD

MEANEY, FJ

机构：

[1] EASTERN KENTUCKY UNIV,RICHMOND,KY 40475

[2] ARIZONA DEPT HLTH SERV,PHOENIX,AZ

[3] VANDERBILT UNIV,MED CTR,SCH MED,DEPT PATHOL,NASHVILLE,TN 37232

[4] VANDERBILT UNIV,MED CTR,SCH MED,DEPT ORTHOPAED & REHABIL,NASHVILLE,TN 37232

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1993年 / 47卷 / 07期

关键词：

METACARPOPHALANGEAL PATTERN PROFILE (MCPP); PATTERN VARIABILITY INDEX; DISCRIMINANT ANALYSIS; CORRELATION STUDIES; DELANGE SYNDROME;

D O I：

10.1002/ajmg.1320470713

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We analyzed the metacarpophalangeal pattern profile (MCPP) of 19 individuals with Brachmann-de Lange syndrome (BDLS) and calculated a mean syndrome profile. Fourteen of 19 individuals with BDLS had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with BDLS compared with a sample of normal individuals produced a correct classification rate of 100% based on a function of 2 MCPP variables that may provide a useful tool for assisting in the diagnosis of BDLS. An average pattern variability index calculated for the BDLS patients was 1.9 indicating an abnormal hand pattern in this syndrome. (C) 1993 Wiley-Liss, Inc.

引用

页码：1003 / 1005

页数：3

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