ENDOTHELIN-1-LIKE IMMUNOREACTIVITY IN CEREBRAL-CORTEX OF ALZHEIMER-TYPE DEMENTIA

被引：38

作者：

MINAMI, M

KIMURA, M

IWAMOTO, N

ARAI, H

机构：

[1] Department of Psychiatry Juntendo University School of Medicine Koshigaya, Saitama

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1995年 / 19卷 / 03期

关键词：

ALZHEIMER-TYPE DEMENTIA; CEREBRAL CORTEX; ENDOTHELIN; ENZYME-IMMUNOASSAY;

D O I：

10.1016/0278-5846(95)00031-P

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Endothelin-1-like immunoreactivity (ET-1-LI) in cerebral cortex in postmortem brains obtained from patients with Alzheimer-type dementia (ATD) was measured by enzyme-immunoassay, 2. The ET-1-LI in the ATD brains was significantly increased in frontal and occipital cortex than those in the control brains and a significant correlation was found between frontal and temporal lobe of ATD brains. 3. These findings may explain the clinico-radiological results that the cerebral blood flow is decreased in ATD patients, the mechanism of which is still unknown.

引用

页码：509 / 513

页数：5

共 11 条

[1]

ARAI H, 1984, J NEUROCHEM, V43, P388

[2] GALANIN HYPERINNERVATES SURVIVING NEURONS OF THE HUMAN BASAL NUCLEUS OF MEYNERT IN DEMENTIAS OF ALZHEIMERS AND PARKINSONS-DISEASE - A HYPOTHESIS FOR THE ROLE OF GALANIN IN ACCENTUATING CHOLINERGIC DYSFUNCTION IN DEMENTIA [J].