DROPLET SIZE MEASUREMENT .1. EFFECT OF 3 INDEPENDENT VARIABLES ON DROPLET SIZE DISTRIBUTION AND SPRAY ANGLE FROM A PNEUMATIC NOZZLE

被引:46
作者
JUSLIN, L [1 ]
ANTIKAINEN, O [1 ]
MERKKU, P [1 ]
YLIRUUSI, J [1 ]
机构
[1] LEIRAS OY,PHARMACEUT R&D,SF-20101 TURKU,FINLAND
关键词
PNEUMATIC NOZZLE; LASER DIFFRACTOMETRY; ATOMIZING AIR PRESSURE; BINDER SOLUTION FLOW RATE; PVP CONCENTRATION; VOLUME DROPLET SIZE DISTRIBUTION; SPRAY ANGLE;
D O I
10.1016/0378-5173(95)00081-S
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
The effect of three independent variables (atomizing air pressure, flow rate of binder solution and polyvinylpyrrolidone concentration) on the droplet size distribution from a pneumatic nozzle was studied using a normal 3(3) factorial design. The droplet sizes and size distributions were determined by laser diffractometry. The effect of the same variables on the spray angle and cross-sectional area of spray cone (describes the area of wetted bed in a fluidized bed granulator) was also evaluated. The dependence of these latter response variables on the independent variables was studied by a multilinear stepwise regression analysis. It was noted that increasing the amount of polyvinylpyrrolidone in binder solution decreased the number of bimodal distributions and increased the width of the distributions. A high pressure with water as a binder solution resulted in a pronounced bimodality and a narrow width of distribution, Increasing the flow rate had no clear; effect on the shape of distributions (uni- or bimodal), but the width of distributions increased. The atomizing air pressure was the most significant factor affecting the spray angle and the cross-sectional area of the spray cone. Increasing the pressure led to a decline in the spray angle and to a decreased area. The effect of PVP concentration was opposite to that of pressure. The effect of flow rate was controversial because, according to the regression analyses, it affected inversely the spray angle and the area.
引用
收藏
页码:247 / 256
页数:10
相关论文
共 12 条
[1]
AULTON M E, 1979, Journal of Pharmacy and Pharmacology, V31, p102P
[2]
CHARACTERISTICS OF PNEUMATIC ATOMIZATION [J].
GRETZINGER, J ;
MARSHALL, WR .
AICHE JOURNAL, 1961, 7 (02) :312-318
[3]
DROP-SIZE DISTRIBUTIONS FROM PNEUMATIC ATOMIZERS [J].
KIM, KY ;
MARSHALL, WR .
AICHE JOURNAL, 1971, 17 (03) :575-&
[4]
Merkku P., 1992, Acta Pharmaceutica Fennica, V101, P173
[5]
Schaefer T., 1977, ARCH PHARM CHEMI SCI, V5, P178
[6]
Schoefer T, 1977, ARCH PHARM CHEMI SCI, V5, P51
[7]
TATE RW, 1953, CHEM ENG PROG, V49, P169
[8]
THURN U, 1970, THESIS EIDGENOSSISCH
[9]
KINETICS AND MECHANISMS OF GROWTH IN BATCH AND CONTINUOUS FLUIDIZED-BED GRANULATION [J].
WALDIE, B ;
WILKINSON, D ;
ZACHRA, L .
CHEMICAL ENGINEERING SCIENCE, 1987, 42 (04) :653-665
[10]
YLIRUUSI J, 1992, PHARM RES-DORDR, V9, pS124