ACROLYSIN, AMINOPROTEINASE CATALYZING INITIAL CONVERSION OF PROACROSIN TO ACROSIN IN MAMMALIAN FERTILIZATION

被引：48

作者：

MCRORIE, RA ^{[1
]}

TURNER, RB ^{[1
]}

BRADFORD, MM ^{[1
]}

WILLIAMS, WL ^{[1
]}

机构：

[1] UNIV GEORGIA, DEPT BIOCHEM, REPROD RES LABS, ATHENS, GA 30602 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 71卷 / 02期

关键词：

D O I：

10.1016/0006-291X(76)90814-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracts of mammalian sperm acrosomes and testes contain a proteinase, acrolysin, that hydrolyzes the aminopeptide bonds of hydrophobic aminoacyl residues. Acrolysin has hydrolytic specificity and properties similar to the proteinase, thermolysin (E.C. 3.4.24.4), that also catalyzes the conversion of proacrosin to acrosin (E.C. 3.4.21.10). Acrolysin is the apparent initiator of proacrosin activation in mammalian fertilization.

引用

页码：492 / 498

页数：7

共 24 条

[1]

ALLISON AC, 1970, J REPROD FERTIL, V21, P501, DOI 10.1530/jrf.0.0210501

[2]

BRADFORD MM, IN PRESS

[3]

Endo S., 1962, J FERMENT TECHNOL, V40, P346

[4]

FRITZ H, 1975, COLD SPRING HARBOR C, V2, P715

[5] ELECTROPHORETIC FRACTIONATION OF BOVINE ACROSOMAL PROTEINS AND PROTEINASE [J].

GARNER, DL ;

SALISBURY, GW ;

GRAVES, CN .

BIOLOGY OF REPRODUCTION, 1971, 4 (01) :93-+

[6] MULTIPLE MOLECULAR-FORMS OF AVIAN ACROSIN - DIFFERENCES IN THEIR KINETIC-PROPERTIES [J].

HO, JJL ;

MEIZEL, S .

FEBS LETTERS, 1975, 56 (01) :115-119

[7]

KOREN E, 1973, J REPROD FERTIL, V32, P349, DOI 10.1530/jrf.0.0320349

[8] THERMOLYSIN - A ZINC METALLOENZYME [J].

LATT, SA ;

HOLMQUIS.B ;

VALLEE, BL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1969, 37 (02) :333-&

[9] BIOCHEMISTRY OF MAMMALIAN FERTILIZATION [J].

MCRORIE, RA ;

WILLIAMS, WL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1974, 43 :777-803

[10] PROACROSIN FROM RABBIT EPIDIDYMAL SPERMATOZOA - PARTIAL-PURIFICATION AND INITIAL BIOCHEMICAL CHARACTERIZATION [J].

MEIZEL, S ;

MUKERJI, SK .

BIOLOGY OF REPRODUCTION, 1975, 13 (01) :83-93

← 1 2 3 →