STUDY OF THE LIPOPHILIC CHARACTER OF XANTHINE AND ADENOSINE DERIVATIVES .1. RM AND LOG P VALUES

被引：42

作者：

BIAGI, GL

GUERRA, MC

BARBARO, AM

BARBIERI, S

RECANATINI, M

BOREA, PA

PIETROGRANDE, MC

机构：

[1] UNIV BOLOGNA,DIPARTIMENTO SCI FARMACEUT,I-40126 BOLOGNA,ITALY

[2] UNIV FERRARA,IST FARMACOL,I-44100 FERRARA,ITALY

[3] UNIV FERRARA,DEPARTIMENTO CHIM,I-44100 FERRARA,ITALY

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 498卷 / 01期

关键词：

D O I：

10.1016/S0021-9673(01)84246-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The RM values of a series of xanthine and adenosine derivatives were measured using silicone reversed-phase thin-layer chromatographic (TLC) and C18 reversed-phase high-performance TLC systems. The two series of data were well correlated. Both were compared with experimental log P and calculated CLOGP values. For xanthine derivatives a good linear relationship was shown between the RM values from the two chromatographic systems and the log P or CLOGP data. For adenosine derivatives the CLOGP values had to be corrected in order to fit the data to the same equation. The TLC data proved to be reliable parameters for describing the lipophilic properties of the test compounds. © 1990.

引用

页码：179 / 190

页数：12

共 23 条

[1] INFLUENCE OF THE MOBILE PHASE-COMPOSITION ON THE REVERSED-PHASE THIN-LAYER CHROMATOGRAPHIC BEHAVIOR OF A SERIES OF PROSTAGLANDINS - COMPARISON OF THE EXTRAPOLATED-RM VALUES [J].