REVERSAL BY TETRAHYDROAMINOACRIDINE OF SCOPOLAMINE-INDUCED MEMORY AND PERFORMANCE DEFICITS IN RATS

被引：47

作者：

MURRAY, TK ^{[1
]}

CROSS, AJ ^{[1
]}

GREEN, AR ^{[1
]}

机构：

[1] ASTRA,NEUROSCI RES UNIT,1 WAKEFIELD ST,LONDON WC1N 1PJ,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1991年 / 105卷 / 01期

关键词：

TETRAHYDROAMINOACRIDINE; PHYSOSTIGMINE; DELAYED NON-MATCH TO SAMPLE; SCOPOLAMINE; RAT;

D O I：

10.1007/BF02316877

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the cholinesterase inhibitors physostigmine and tetrahydroaminoacridine (THA) on memory and performance deficits induced by scopolamine were studied using an operant delayed non-matching to position task. No effect was seen on the performance of rats when treated with either physostigmine (0.1 mg/kg IP) or THA (1 mg/kg IP) alone. However, the performance deficits induced in the task by scopolamine (0.03 mg/kg SC) were reversed by the same doses of the cholinesterase inhibitors.

引用

页码：134 / 136

页数：3

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