INHIBITION OF HOMOLOGOUS COMPLEMENT ACTIVATION BY THE HEAT-STABLE ANTIGEN

被引:10
作者
HISTUMOTO, Y
OHNISHI, H
NAKANO, A
HAMADA, F
SAHEKI, S
TAKEUCHI, N
机构
[1] EHIME UNIV,SCH MED,DEPT ANESTHESIOL,SHIGENOBU,EHIME 79102,JAPAN
[2] OSAKA UNIV,MICROBIAL DIS RES INST,DEPT ONCOGENE RES,SUITA,OSAKA 565,JAPAN
关键词
MOUSE ERYTHROCYTE; GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED PROTEIN;
D O I
10.1093/intimm/5.7.805
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The murine heat-stable antigen (HSAg) is of particular interest due to its unique tissue distribution. HSAg is expressed on most thymocytes, bone marrow cells, immature B cells, and erythrocytes, but not on peripheral T and mature B cells. Although HSAg has been thought to be a differentiation antigen, its actual biological significance remains unknown except for the HSAg on antigen presenting cells. Recently, a new rat anti-HSAg mAb, R13, has been developed. Here it has been found that the mouse complement activation on mouse erythrocytes, but not the human, guinea pig or rabbit complement activations, was enhanced in the presence of the Fab fragment of R13. Affinity-purified HSAg derived from mouse erythrocytes could be passively incorporated into rabbit erythrocytes because of its molecular characteristic of glycosyl-phosphatidyl inositol-anchored protein. Mouse complement activation, but not guinea pig complement activation, was partially suppressed on the HSAg-incorporated rabbit erythrocytes. These findings suggest that HSAg has a homologous complement regulating activity.
引用
收藏
页码:805 / 808
页数:4
相关论文
共 29 条
[1]   CHARACTERIZATION OF THE MURINE HEAT-STABLE ANTIGEN - AN HEMATOLYMPHOID DIFFERENTIATION ANTIGEN DEFINED BY THE J11D, M1/69 AND B2A2 ANTIBODIES [J].
ALTERMAN, LA ;
CRISPE, IN ;
KINNON, C .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (07) :1597-1602
[2]  
BRUCE J, 1981, J IMMUNOL, V127, P2496
[3]   GLYCOLIPID ANCHORING OF PLASMA-MEMBRANE PROTEINS [J].
CROSS, GAM .
ANNUAL REVIEW OF CELL BIOLOGY, 1990, 6 :1-39
[4]   CD59, AN LY-6-LIKE PROTEIN EXPRESSED IN HUMAN LYMPHOID-CELLS, REGULATES THE ACTION OF THE COMPLEMENT MEMBRANE ATTACK COMPLEX ON HOMOLOGOUS CELLS [J].
DAVIES, A ;
SIMMONS, DL ;
HALE, G ;
HARRISON, RA ;
TIGHE, H ;
LACHMANN, PJ ;
WALDMANN, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (03) :637-654
[5]   REGULATION OF THE AMPLIFICATION C-3 CONVERTASE OF HUMAN-COMPLEMENT BY AN INHIBITORY PROTEIN ISOLATED FROM HUMAN-ERYTHROCYTE MEMBRANE [J].
FEARON, DT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (11) :5867-5871
[6]  
HANSCH GM, 1988, BLOOD, V72, P1089
[7]  
HITSUMOTO Y, 1984, IMMUNOLOGY, V53, P847
[8]   PURIFICATION OF THE MURINE HEAT-STABLE ANTIGEN FROM ERYTHROCYTES [J].
HITSUMOTO, Y ;
NAKANO, A ;
OHNISHI, H ;
HAMADA, F ;
SAHEKI, S ;
TAKEUCHI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 187 (02) :773-777
[9]   NECTADRIN, THE HEAT-STABLE ANTIGEN, IS A CELL-ADHESION MOLECULE [J].
KADMON, G ;
ECKERT, M ;
SAMMAR, M ;
SCHACHNER, M ;
ALTEVOGT, P .
JOURNAL OF CELL BIOLOGY, 1992, 118 (05) :1245-1258
[10]  
KAMEYOSHI Y, 1989, IMMUNOLOGY, V68, P439