SUPPORT FOR THE SHAPE CONCEPT OF LIPID STRUCTURE-BASED ON A HEADGROUP VOLUME APPROACH

被引：45

作者：

LEE, YC ^{[1
]}

TARASCHI, TF ^{[1
]}

JANES, N ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,COLL MED,DEPT PATHOL & CELL BIOL,1020 LOCUST ST,PHILADELPHIA,PA 19107

来源：

BIOPHYSICAL JOURNAL | 1993年 / 65卷 / 04期

关键词：

D O I：

10.1016/S0006-3495(93)81206-2

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Headgroup volumes of seven dioleoyl lipid species, calculated from covalent radii, are shown to correlate linearly (r = 0.95) with the ability of those lipids to alter the midpoint temperature of the lamellar to inverted hexagonal phase transition (L(alpha) --> H(II)) of a 95 mole fraction percent phosphatidylethanolamine matrix. The results illustrate the utility of the shape concept and basic considerations of headgroup volume as a predictive tool for the determination of lipid structure.

引用

页码：1429 / 1432

页数：4

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