ALTERNATIVELY SPLICED ISOFORMS OF THE NMDAR1 GLUTAMATE RECEPTOR SUBUNIT - DIFFERENTIAL EXPRESSION IN THE BASAL GANGLIA OF THE RAT

被引：55

作者：

STANDAERT, DG

TESTA, CM

PENNEY, JB

YOUNG, AB

机构：

[1] Department of Neurology, Massachusetts General Hospital, Boston

来源：

NEUROSCIENCE LETTERS | 1993年 / 152卷 / 1-2期

关键词：

N-METHYL-D-ASPARTATE RECEPTOR; MESSENGER RNA; LIGAND-GATED ION CHANNEL; BASAL GANGLIA; SUBTHALAMIC NUCLEUS;

D O I：

10.1016/0304-3940(93)90508-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several isoforms of the NMDAR1 glutamate receptor subunit are produced by alternative mRNA splicing of three cassette sequences. Using in situ hybridization with exon-specific probes, we have observed differential regional expression of a cassette in the amino terminus of the NMDAR1 subunit, Insertion I, which confers distinct structural and physiologic properties. The differential distribution of expression is most prominent in the basal ganglia, where only the subthalamic nucleus expresses the insertion at high levels.

引用

页码：161 / 164

页数：4

共 20 条

[1] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS
ALBIN, RL
YOUNG, AB
PENNEY, JB
[J]. TRENDS IN NEUROSCIENCES, 1989, 12 (10) : 366 - 375
[2] BASIC LOCAL ALIGNMENT SEARCH TOOL
ALTSCHUL, SF
GISH, W
MILLER, W
MYERS, EW
LIPMAN, DJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
[3] COMBINATORIAL RNA SPLICING ALTERS THE SURFACE-CHARGE ON THE NMDA RECEPTOR
ANANTHARAM, V
PANCHAL, RG
WILSON, A
KOLCHINE, VV
TREISTMAN, SN
BAYLEY, H
[J]. FEBS LETTERS, 1992, 305 (01) : 27 - 30
[4] GAMMA-AMINOBUTYRIC ACIDA RECEPTOR HETEROGENEITY IS INCREASED BY ALTERNATIVE SPLICING OF A NOVEL BETA-SUBUNIT GENE TRANSCRIPT
BATESON, AN
LASHAM, A
DARLISON, MG
[J]. JOURNAL OF NEUROCHEMISTRY, 1991, 56 (04) : 1437 - 1440
[5] THE HUMAN MUSCLE NICOTINIC ACETYLCHOLINE-RECEPTOR ALPHA-SUBUNIT EXISTS AS 2 ISOFORMS - A NOVEL EXON
BEESON, D
MORRIS, A
VINCENT, A
NEWSOMDAVIS, J
[J]. EMBO JOURNAL, 1990, 9 (07) : 2101 - 2106
[6] REVERSAL OF EXPERIMENTAL PARKINSONISM BY LESIONS OF THE SUBTHALAMIC NUCLEUS
BERGMAN, H
WICHMANN, T
DELONG, MR
[J]. SCIENCE, 1990, 249 (4975) : 1436 - 1438
[7] CLONING OF AN APPARENT SPLICE VARIANT OF THE RAT N-METHYL-D-ASPARTATE RECEPTOR NMDAR1 WITH ALTERED SENSITIVITY TO POLYAMINES AND ACTIVATORS OF PROTEIN-KINASE-C
DURAND, GM
GREGOR, P
ZHENG, X
BENNETT, MVL
UHL, GR
ZUKIN, RS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) : 9359 - 9363
[8] MALOSIO ML, 1991, J BIOL CHEM, V266, P2048
[9] CHARACTERIZATION AND REGIONAL DISTRIBUTION OF STRYCHNINE-INSENSITIVE [H-3] GLYCINE BINDING-SITES IN RAT-BRAIN BY QUANTITATIVE RECEPTOR AUTORADIOGRAPHY
MCDONALD, JW
PENNEY, JB
JOHNSTON, MV
YOUNG, AB
[J]. NEUROSCIENCE, 1990, 35 (03) : 653 - 668
[10] THE EXCITATORY AMINO-ACID RECEPTORS - THEIR CLASSES, PHARMACOLOGY, AND DISTINCT PROPERTIES IN THE FUNCTION OF THE CENTRAL NERVOUS-SYSTEM
MONAGHAN, DT
BRIDGES, RJ
COTMAN, CW
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1989, 29 : 365 - 402

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