GLYCOPROTEIN-B OF BOVINE HERPESVIRUS TYPE-4 - ITS PHYLOGENETIC RELATIONSHIP TO GB EQUIVALENTS OF THE HERPESVIRUSES

被引：38

作者：

GOLTZ, M ^{[1
]}

BROLL, H ^{[1
]}

MANKERTZ, A ^{[1
]}

WEIGELT, W ^{[1
]}

LUDWIG, H ^{[1
]}

BUHK, HJ ^{[1
]}

BORCHERS, K ^{[1
]}

机构：

[1] FREE UNIV BERLIN, INST VIROL, D-13353 BERLIN, GERMANY

来源：

VIRUS GENES | 1994年 / 9卷 / 01期

关键词：

BHV-4; GB; GAMMA-HERPESVIRUS; SEQUENCE ALIGNMENT; CONSERVED DOMAINS; EVOLUTIONARY TREE;

D O I：

10.1007/BF01703435

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In order to estimate the phylogenetic relationship of BHV-4 among the herpesviruses, we have cloned and sequenced its glycoprotein B (gB). The 2.6 kb open reading frame codes for a 874 amino acid long protein. The comparison of its deduced amino acid sequence with those of its counterparts in 19 distinct herpesviruses groups BHV-4 into the gamma-herpesvirinae, The calculation of an evolutionary tree emphasized that BHV-4 is more closely related to herpesvirus saimiri (HVS) than to Epstein-Barr virus (EBV). However, in contrast to EBV and HVS, the gB of BHV-4 contains a putative protease cleavage site and 20 potential N-glycosylation sites. The alignment of the amino acid sequences revealed that 10 cysteine and 7 proline residues, as well as the motifs SPF and GQLG, were completely conserved among the 20 investigated gBs.

引用

页码：53 / 59

页数：7

共 47 条

[1] STRUCTURAL ORGANIZATION OF THE CONSERVED GENE BLOCK OF HERPESVIRUS-SAIMIRI CODING FOR DNA-POLYMERASE, GLYCOPROTEIN-B, AND MAJOR DNA-BINDING PROTEIN
ALBRECHT, JC
FLECKENSTEIN, B
[J]. VIROLOGY, 1990, 174 (02) : 533 - 542
[2] DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME
BAER, R
BANKIER, AT
BIGGIN, MD
DEININGER, PL
FARRELL, PJ
GIBSON, TJ
HATFULL, G
HUDSON, GS
SATCHWELL, SC
SEGUIN, C
TUFFNELL, PS
BARRELL, BG
[J]. NATURE, 1984, 310 (5974) : 207 - 211
[3] CONSERVED EPITOPES OF SIMIAN HERPESVIRUS SA-8 AND BOVINE HERPESVIRUS TYPE-2
BORCHERS, K
OZEL, M
PAULI, G
GELDERBLOM, HR
LUDWIG, H
[J]. ARCHIVES OF VIROLOGY, 1990, 111 (1-2) : 1 - 14
[4] CONSERVED DOMAINS OF GLYCOPROTEIN-B (GB) OF THE MONKEY VIRUS, SIMIAN AGENT-8, IDENTIFIED BY COMPARISON WITH HERPESVIRUS GBS
BORCHERS, K
WEIGELT, W
BUHK, HJ
LUDWIG, H
MANKERTZ, J
[J]. JOURNAL OF GENERAL VIROLOGY, 1991, 72 : 2299 - 2304
[5] BREATHNACH R, 1981, ANNU REV BIOCHEM, V50, P349, DOI 10.1146/annurev.bi.50.070181.002025
[6] GENETIC-RELATIONSHIPS BETWEEN BOVINE HERPESVIRUS-4 AND THE GAMMAHERPESVIRUSES EPSTEIN-BARR-VIRUS AND HERPESVIRUS SAIMIRI
BUBLOT, M
LOMONTE, P
LEQUARRE, AS
ALBRECHT, JC
NICHOLAS, J
FLECKENSTEIN, B
PASTORET, PP
THIRY, E
[J]. VIROLOGY, 1992, 190 (02) : 654 - 665
[7] THE NUCLEOTIDE-SEQUENCE OF THE GB GLYCOPROTEIN GENE OF HSV-2 AND COMPARISON WITH THE CORRESPONDING GENE OF HSV-1
BZIK, DJ
DEBROY, C
FOX, BA
PEDERSON, NE
PERSON, S
[J]. VIROLOGY, 1986, 155 (02) : 322 - 333
[8] NUCLEOTIDE-SEQUENCE SPECIFYING THE GLYCOPROTEIN GENE, GB, OF HERPES-SIMPLEX VIRUS TYPE-1
BZIK, DJ
FOX, BA
DELUCA, NA
PERSON, S
[J]. VIROLOGY, 1984, 133 (02) : 301 - 314
[9] ROLE OF GLYCOPROTEIN-B OF HERPES-SIMPLEX VIRUS TYPE-1 IN VIRAL ENTRY AND CELL-FUSION
CAL, WH
GU, BH
PERSON, S
[J]. JOURNAL OF VIROLOGY, 1988, 62 (08) : 2596 - 2604
[10] HOMOLOGY OF THE ENVELOPE GLYCOPROTEIN-B OF HUMAN HERPESVIRUS-6 AND CYTOMEGALOVIRUS
CHOU, SW
MAROUSEK, GI
[J]. VIROLOGY, 1992, 191 (01) : 523 - 528

← 1 2 3 4 5 →